378 LECTUKE XV. 



sebaceous matter ; they are produced by the c*. alescence 

 of the minute granules which appear in the secretion of 

 colostrum. 



Now that we have seen these types of physiological 

 transformation, gentlemen, the description of the patho- 

 logical changes no longer offers any difficulty. With 

 the exception of very few structures, as for example, 

 red blood-corpuscles ,and the nerve-fibres in the great 

 nervous centres, nearly all other cellular parts may 

 under certain circumstances undergo a similar metamor- 

 phosis, which displays itself in a precisely similar man- 

 ner, that is, isolated, extremely minute globules of fat 

 appear in the cell-contents, become more abundant, and 

 gradually fill up the cell-cavity, without, however, run- 

 ning together into such large drops, as is the case in 

 fatty infiltration and in the adipose-tissue formations. 

 Usually, the development of the fat-granules first de- 

 clares itself at some distance from the nucleus ; very 

 seldom does it begin at the nucleus. This is the cell 

 which has long been called the granule-cell. Then 

 conies a stage, in which the nucleus and membrane are 

 indeed still to be seen, but the fat-granules lie as close 

 to one another as in colostrum corpuscles ; only at the 

 spot where the nucleus lay, there is still a little gap 

 (Fig. 66, b). From this stage there is but a short step 

 to the complete destruction of the cell. For a cell 

 never remains for any length of time in the state of a 

 granule-cell, but as soon as it has once entered into this 

 stage, the nucleus generally disappears at once, and 

 ultimately the membrane also, probably by a species of 

 solution. Then we have the simple granule- globule, or as 

 it was formerly called, inflammatory globule [exudation- 

 corpuscle], which Gluge first described under this name 

 (Fig. 66, e). 



Gluge in this made one of those mistakes which not 



