LECTURE XVI I. 



APRIL 17, 1858. 

 AMYLOID DEGENERATION. INFLAMMATION. 



Amyloid (Uirdaceous or waxy) degeneration Different nature of amyloid sub- 

 stances : concentric and laminated amyloid bodies (brain, prostate), and amy- 

 loid degeneration properly so-called Its course Commencement of the affec- 

 tion in the minute arteries Waxy liver -Cartilage Dyscrasic (constitutional) 

 character of the disease Intestines Kidneys: the three forms of Bright's 

 disease (amyloid degeneration, parenchymatous, and interstitial nephritis) 

 Lymphatic glands Functional disturbances of the affected organs. 



Inflammation The four cardinal symptoms and their predominance in the different 

 schools: the thermic and vascular theory ; the neuro-pathologists, exudations 

 Inflammatory stimuli Lesion of function Exudation as a consequence of 

 the activity of the tissues ; mucus and fibrine Inflammation as a complex 

 irritative process Parenchymatous and exudative (secretory) form. 



I WILL to-day, gentlemen, from among the changes 

 which must in general be rather ranked with that class 

 of degenerations which are attended with a diminution 

 of functional power, introduce to your notice one, which 

 has recently acquired especial interest, namely that 

 which has been by some called the lardaceous (bacony 

 speckig), by others the waxy, whilst I have given it the 

 name of the amyloid, change. The term lardaceous 

 change has again come more into use chiefly through 

 the instrumentality of the Vienna school. You know 

 that the term itself is of tolerably ancient date in medi- 

 cine as a denomination for a firm, compact, homogeneous 



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