LECTURE XVIII. 



APRIL 21, 1858. 

 NORMAL AND PATHOLOGICAL NEW-FORMATION. 



The theory of continuous development in opposition to the blastema- and exuda- 

 tion-theory Connective tissue and its equivalents as the most general germ- 

 store of new formations Correspondence between embryonic and pathologi- 

 cal new formation Cell-division as the most general starting-point of new 

 formations. 



Endogenous formation Physalides Brood-cavities 



Different tendencies of new-formations Hyperplasia, direct and indirect Htero 

 plasia Pathological formative cells Difference in their size and in the time 

 required for their full development. 



Description of the development of bone as a model formation Difference between 

 formation and transformation Fresh and growing, in opposition to macerated, 

 bone Nature of medullary tissue Growth in length of tubular [long] bones ; 

 proliferation of cartilage Formation of marrow as a transformation of tissue ; 

 red and yellow, normal and inflammatory marrow Osseous tissue, calcified 

 cartilage, osteoid tissue Bone territories: caries, degenerative ostitis Granu- 

 tions in bone Suppuration of bone Maturation of pus Ossification of mar- 

 row Growth of long bones in thickness : structure and proliferation of the 

 periosteum. 



Granulations as analogous to the medulla of bor.es, and as the starting-point of all 

 heteroplastic development. 



GENTLEMEN, I propose to-day, in illustration of for- 

 mative irritation, to portray to you the most import- 

 ant features in the history of pathological new-forma- 

 tions, for a knowledge of these will throw light upon a 

 series of events which present themselves both in the 

 more complicated formation of tumours, and in the 

 more simple inflammatory irritative processes. That I 



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