TYPHOUS MATTER. THE 1 CONNECTIVE-TISSUES. 439 



at present entirely reject the blastema doctrine in its 

 original form, you have no doubt already gathered from 

 the previous lectures. In its place I have put the very 

 simple doctrine of the continuous development . of tissues 

 out of one another. The chief point therefore in indi- 

 vidual cases is to determine the particular manner in 

 which the various tissues arise, and by means of definite 

 examples to make oneself acquainted with all the 

 different directions which it is possible this development 

 may follow. 



My first observations, in consequence of which I began 

 to entertain doubts with respect to the prevailing blaste- 

 ma and exudation doctrine as to how far namely, new- 

 formations could be derived from this source date from 

 researches of mine on tubercle.* I found namely that a 

 series of tubercular deposits in different organs, espe- 

 cially in the lymphatic glands, the membranes of the 

 brain and the lungs, never at any time exhibited a 

 discernible exudation, but always, during the whole 

 course of their development, presented organized ele- 

 ments, without its ever being possible to observe either 

 in them, or before they existed, any stage in which 

 amorphous, shapeless matter was present. As long as 

 eight years ago I discerned that the development which 

 takes place in the lymphatic glands upon the occurrence 

 of the well-known scrofulous changes, begins in such a 

 way, that the first conditions met with entirely corres- 

 pond to those which in other instances are designated 

 by the name of hypertrophy ; for nuclei and cells are 

 found in great abundance, though they afterwards break 

 up and directly supply the material for the final accumu- 

 lation of cheesy substance. The view which I derived 



* See a paper on tuberculosis and its relations to inflammation, scrofulosis and 

 typhoid fever. Verliandlungen der physikalisch medic. Gesel) -chaft zu Wnrzburg, 

 1850, vol. i., p. 81. 



