LIVER. 201 



They are large, finely granular cells, possessing phagocytic 

 properties. They are found containing foreign materials, and 

 red and white blood-corpuscles. 



The lymph-vessels form a thick plexus in the capsule of the 

 liver, which sends branches into the interlobular connective 

 tissue. From between the lobules fine lymph-vessels proceed 

 along the intralobular capillaries, not as closed channels, but as 

 perivascular lymph spaces. These surround the blood capil- 

 laries and stand in close relation with them. 



The relations of the lymphatics of the liver have been 

 studied by F. P. Mall, upon whose description the following 

 account is based : The forcing of a colored fluid into the bile 

 duct causes an injection of the liver lymphatics. This is 

 accomplished through the perivascular lymph spaces sur- 

 rounding the blood capillaries. The walls of the blood capil- 

 laries consist of a layer of interlacing reticulum fibrils, upon 

 which is placed an incomplete layer of the endothelial cells of 

 v. Kupffer. The capillary walls are thus quite porous, and 

 there is but little resistance to the passage of fluids from the 

 capillaries into the perivascular spaces. By filling the blood- 

 vessels of the liver with a colored injection mass, an injection 

 of the perivascular spaces and lymphatics is also brought about. 

 The perivascular space communicates directly with what Mall 

 terms the perilobular space which exists between the liver cells 

 at the periphery of the lobule and the interlobular connective 

 tissue. The perilobular space in turn communicates with the 

 lymph radicals by means of the interlobular connective-tissue 

 spaces. " There are no direct channels connecting the peri- 

 vascular and perilobular spaces with the lymphatics proper 

 other than the ordinary spaces between the connective-tissue 

 fibrils of the capsule of Glisson" (Mall). 



The nerves of the liver are in large part non-medullated. 

 They form plexuses in the interlobular connective tissue 

 around the blood-vessels and bile passages. Some of the 

 branches from these networks end in the interlobular struct- 

 ures, while others enter the lobules, to accompany the bile 



