J-M) MIcnnscnTK' .LY.17'oj/r Of THE 



In the beginning a chromatolysis or karyolysis takes place in 

 the nucleus. The chromatin becomes granular, and finally is 

 dissolved and the nuclear membrane disappears. On the other 

 hand, the nucleus may undergo simple atrophy. In the cell 

 hody, at the same time, fatty degeneration sets in, and the pro- 

 toplasm becomes gradually liquefied. The zona pellucida 

 swells, and finally is dissolved. These changes in the ovum 

 are followed immediately by similar degenerations in the folli- 

 cular cells. The absorption and disappearance of the dead 

 cells are brought about mainly by phagocytic wandering cells. 



This destruction of cells often leads to a new formation of 

 tissue in the theca interim, consisting in the production of a 

 fibrillar connective-tissue scar (Schottlander). Among the 

 cells sometimes are found karyokinetic figures (Flemming). 



The blood-vessels of the ovary arise on the arterial side from 

 the ovarian and the uterine arteries. Branches of these enter 

 the medulla through the hilum, and take a characteristic tor- 

 tuous, corkscrew-shaped course. They divide many times, and 

 the smaller branches diverge to the peripheral part of the 

 medulla, where they form a rich plexus. From this, branches 

 enter the cortex, and, spreading through the stroma, form 

 capillary networks in the theca folliculi. 



The lymph- vessels surround the Graafian follicle with a 

 network and leave the ovary through numerous wide trunks 

 in the hilum. 



The nerves, partly meduilated and partly non-medullated, 

 (inter the ovary through the hilum, following the course of the 

 blood-vessels, in whose walls a 'great many fibres end. Other 

 fibres reach the germinal epithelium and surround the follicles 

 with dense networks. According to Retzius, and others, the 

 nerve fibres do not enter the follicle, while Riese and v. Herif 

 have found the nerve-endings between the follicular epithelial 

 cells. 



Among the rudimentary organs found in the neighborhood 

 of the ovary and derived from the Wolffian body are the 

 epoophoron (parovarium, organ of Rosenmiiller) and the 

 paroophoron. The first lies in the broad ligament at the hilum 



