Effect of Internal Influences. 



The reaction again appeared when the secretion became of a milk- 

 like consistency. 



Affected milk behaves in various ways on the application 

 of f ormalin-methylene blue solution ; frequently a very rapid decol- 

 oration of Schardinger's reagent may be observed (Rullmann, Sas- 

 senhagen, Rievel). Sometimes in typically changed samples the 

 reduction does not take place (author's observation). 



As the above-mentioned enzymes (not amylase), at least in 

 part may appear to be brought on by bacterial action, their abnor- 

 mal presence in milk has a diagnostic importance only in freshly 

 milked samples. The case is different with the complement con- 

 tent. As indicated in the chapter on antigens, blood constituents 

 pass directly into the milk during periods of physiological and 

 pathological irritations. Therefore in mastitis, as proved by 

 Bauer and Sassenhagen, complements are demonstrable in the 

 milk. This, according to Sassenhagen, is possible even in affec- 

 tions in which the Trommsdorff value of the centrifugalized cells 

 per 1000 parts of milk is still remarkably slight. 



The alkaline reaction of affected milk, the altered proportions 

 of mineral salts, at times the passing into the milk of bloody parti- 

 cles, and the diminution of casein, reduce the coagulability of the 

 milk towards added rennet. Affected milk therefore generally 

 utilizes a considerably larger quantity of rennet than normal milk 

 before it becomes coagulated (Schern). 



The spontaneous coagulation of affected milk also appears to 

 be considerably delayed. 



Infectious Agents of Mastitis. 



Nocard and Mollereau, Kitt, Lucet, Bang, Guillebeau and 

 Hess, Zschokke, Jensen, Streit, Glage and Sven Wall have offered 

 sufficient information regarding the infectious agents of the dif- 

 ferent forms of mastitis. 



Most cases of mastitis are produced by streptococci; they 

 consist of chronic inflammations of one or more quarters of the ud- 

 der. The disease is of relatively small influence on the general 

 condition of the animal. 



Bacilli of the coli-aerogenes-paratyphus-paracolon groups pro- 

 duce highly acute, parenchymatous lesions. The general condition 

 is severely influenced through infections by bacteria of the 

 paratyphus-B group. Locally a gangrenous, septic mastitis de- 

 velops with this infection, and the milk is markedly ichorous, 

 while in colon infections the secretion is of a serum-like character 

 (Weichel). 



A third form of inflammation of the udder, also of a chronic 

 nature, is produced by a representative of the group of the 

 Bacillus pyogenes, Sven Wall's pyobacillosis of the udder. The 

 Bacillus pyogenes colonizes with a special predilection in the pres- 



