976 



THE INTERNAL SECRETIONS 



mellitus, because the metabolism of the sugars is interfered with in this 

 disease in a much more extensive manner. 1 Since the action of 

 adrenalin seems to be concentrated upon the liver, it cannot surprise 

 us to find that it also incites a more copious discharge of other products. 

 Thus, Cannon 2 has found that the intravenous injection of this agent 

 in amounts of 0.0001 mgr. per kilo of body weight (cats) shortens 

 the coagulation-time of the blood. In addition, it has been shown by 

 Cannon and Nice 3 as well as by Gruber 4 that this procedure is followed 

 by a temporary improvement in the power of contraction of fatigued 



d e j 



FIG. 509. MEDIAN SAGITTAL SECTION THROUGH PITUITARY OF MONKEY; SEMIDIAGRAM- 



MATIC. (Herring.) 



a. Optic chiasma; b, third ventricle; c, g, pars intermedia; d, epithelium of pars 

 intermedia extending round neck of pars nervosa; e, pars glandularis seu epithelialis ; /, 

 intraglandular cleft, lying between pars glandularis' (e) and pars intermedia (g); h, 

 pars nervosa. 



muscles, a change which, owing to the small doses employed, cannot be 

 due to improved circulatory conditions. More recently, it has been 

 pointed out by Hartmann and Fraser 5 that subminimal doses of this 

 agent give rise to a vasodilatation. It should be remembered, how- 

 ever, that these effects have been obtained under experimental con- 

 ditions and that they do not justify the deduction that they also occur 

 normally in consequence of the outpouring of varying amounts of 

 adrenin. 



1 Lusk and Riche, Arch. Int. Med., xiii, 1914, 673. 



2 Am. Jour, of Physiol., xxxiv, 1914, 255. 

 8 Ibid., xxxii, 1913, 44. 



4 Ibid., xxiii, 1914, 335, also: Endocrinology, in, 1919, 145. 

 6 Ibid., xliv, 1917, 353. 



