THE SYNTHESIS OF THE PROTEINS 



POLYPEPTIDES SYNTHESISED BY METHOD I. 



Glycine ester 



Alanine ester - 



Leucine ester - 



Diaminopropionic acid ester 



Histidine ester - 



Lysine ester - 



Arginine ester 



Serine ester - 



Isoserine ester 



Tyrosine methyl ester - 



Aspartic acid methyl ester - 



Simple Polypeptides. 



glycine anhydride -* glycyl-glycine. 



alanine anhydride > alanyl-alanine. 



leucine anhydride > leucyl-leucine. 



-> diaminopropionic acid anhydride. 



histidine anhydride 

 lysine anhydride 



serine anhydride 



histidyl-histidine. 

 lysyl-lysine. 

 arginyl-arginine (?) 

 seryl-serine. 

 isoseryl-isoserine. 

 tyrosyl-tyrosine. 



diketopiperazine diacetic diamide 

 by action of ammonia. 



tyrosine anhydride 

 aspartic acid anhydride - 

 2-5-diketopiperazine, 3-6- 



diacetic acid 



pentaglycyl-glycine ester - pentaglycyl-glycine. 

 octaglycine anhydride (?) 

 1-alanyl-glycyl-glycine methyl ester -> 1-alanyl-diglycyl-l-alanyl-glycyl-glycine 



Diglycyl-glycine methyl 

 ester 



Leucyl-alanine anhydride 

 Leucyl-proline anhydride 



I from dipeptide. 



Chloracetyl alanine ester 



Chloracetyl tyrosine ester 



Glycyl-1-phenylalanine ester 

 1-phenylalanyl-glycine ester 



Leucyl-glycine ester 

 Glycyl-aspartic acid ester 



Phenylalanyl-glycine ester 

 Valyl-glycine ester 

 Valyl-alanine ester 



Mixed Polypeptides. 

 Glycyl-alanine anhydride 

 glycyl-1-tyrosine anhydride 



glycyl-1-phenylalanine anhydride 



leucyl-glycine anhydride 

 glycyl-aspartic acid anhydride 

 leucyl-alanine anhydride 



Phenylalanyl-glycine anhydride. 

 Valyl-glycine anhydride. 

 Valyl-alanine anhydride. 



glycyl-alanlne. 

 alanyl-glycine. 

 glycyl-1-tyrosine. 

 1-tyrosyl-glycine. 



leucyl-glycine. 

 g'ycyl-leucine. 



leucyl-alanine. 

 alanyl-leucine. 



