TABLE OF CONTENTS 



CHAPTER I 



PAGE 



COLLOID CHEMISTRY AND THE GENERAL CHEMISTRY OF THE 



PROTEINS * 



General development of colloid chemistry. A sharp demar- 

 cation originally supposed to exist between colloidal and 

 molecular disperse systems. Increase in our knowledge of 

 transitional stages. The colloid chemistry and general physi- 

 cal chemistry of the proteins form an inseparable whole. 

 Connection between these aspects and structural chemistry. 



CHAPTER II 



CONDITIONS OF STABILITY IN PROTEIN SOLUTIONS . .10 



The bearing on stability of the colloid particles of (i.) hydra - 

 tion, (ii.) electric charge. Lyophobe and lyophile colloids. 

 Connection between electric charge and hydration of the 

 particles. Origin of the electric charge. Nature of the pre- 

 cipitation process. Proteins with hydrophobe and those with 

 hydrated neutral particles. Classification of the alterations 

 in state in colloid systems. Reversible and irreversible trans- 

 formations ; homodrome and heterodrome reversible changes. 



CHAPTER III 

 THE ELECTRIC CHARGE ON NATURAL SOLUBLE ALBUMIN . . 19 



Determination of the iso-electric reaction with the electro- 

 phoresis apparatus. Amphoteric electrolytes. Hydrion regu- 

 lators. Dissociation constants of amphoteric electrolytes. 

 Chemical constitution and magnitude of dissociation con- 

 stants. Theory of the iso-electric reaction. Equality in con- 

 centration of albumin anions and cations ; maximum concen- 

 tration of neutral protein particles at the iso-electric point. 



CHAPTER IV 

 PROPERTIES OF PROTEINS IN ISO-ELECTRIC REACTION . . 37 



Neutral and ionised albumin difference in their properties. 

 Determination of the iso-electric point from the maximum of 

 neutral albumin particles as found by precipitation by 

 alcohol, by viscosity measurements, by osmotic pressure, and 

 by imbibition. Dependence of the iso-electric reaction on the 

 concentration of albumin. Difference in behaviour with weak 

 and strong acids. Sorensen's new method of determining the 

 iso-electric point. 



