specifically from both of those described in the Reports of the Bureau of Animal 

 Industry ? 



Please make such suggestions as may occur to you in the course of your investiga- 

 tions in regard to tho pr(ip»r jijettiod of treating and preventing these diseases. The 

 report of t|i&J9oard,8la©uld«b« sufemitted to me on or before April 1, 1889. 

 Yery respe^tfullyj ^ . ' . 



/', ;*•:•'.:.'**•'*;: '• .*\ '^ Norman J. Colman, 



«•.••••*•*.' ,t.... .••• Commissioner of Agnoulture. 



Dr. E. O. Shakespeare, 



1336 Spruce street, Philadelphia, Pa. 



(Note.— Professor Welch declined, and Prof. B. Meade Bolton, of the 

 University of South Carolina, was appointed in his stead.) 



Modifications of the letter of instructions were made with one mem* 

 ber of the Commission, viz., Professor Burrill, before his acceptance 

 of his appointment j but as these were not made with the other mem- 

 bers, they are not here inserted. 



In fulfillment of the object of their commission, as explained by the 

 accompanying instructions, the Commissioners met at Washington 

 during the week of last Christmas and organized by the election of 

 Dr. Shakespeare as chairman, and Prof. B. Meade Bolton as secretary. 

 They sketched out a plan of work as follows : 



(1) Examine methods of observation and research pursued in the 

 Bureau of Animal Industry at Washington. 



(2) Examine diseased hogs furnished by the Bureau of Animal In- 

 dustry, making special endeavor to find the two diseases described by 

 the Bureau authorities and the two germs claimed by them to be the 

 cause of tlie respective maladies. 



(3) Visit South Carolina for the purpose of examining into the nature 

 and cause of epidemic diseases among hogs, prevalent there. 



(4) Visit Nebraska for the purpose of examining the methods of Dr. 

 Billings and the disease upon which he was at work. 



(5) Examine into nature and cause of disease among hogs in various 

 localities in that State. 



(6) Visit as many outbreaks of swine disease in different parts of the 

 country as possible with a view of finding if such existed — the two dis- 

 eases and the two germs described by the Bureau authorities. 



(7) Visit Dr. Detmers to examine his claims of priority and his 

 methods of investigation. 



(8) Examine separately and individually the morphological and 

 pathogenic qualities of the germs found in the various localities where 

 the Commission might find epidemics prevalent among hogs. 



(9) Examine the question of immunity after a natural attack and 

 after artificial inoculation from the stand-point of experience in Ne- 

 braska. 



(10) Test especially the question of artificial immunity by experi- 

 mentation at Philadelphia upon inoculated and recovered pigs obtained 

 in Nebraska, as compared with controls. 



