DISEASES OF THE OX AND SHEEP. 



29^ 



rabid rabbit. The inoculations were repeated on the following 

 days, namely : — 



On July 7, at 9 a.m., with marrow of 14 days. 



„ 12 „ 



„ 11 „ 



>> >> 9 >» 



„ „ 8 „ 



J) if > ft 



„ 6 „ 



>> M 5 ,, 



}f >} '* if 



Q 



Jf )) " }f 



15 ,, 11 ,, _,, ,, A _,, 



Id ,, J.J. ,, ., ,. X ,1 



Thus thirteen inoculations were made in eleven days. Two 

 fresh rabbits were trepanned with the various marrows, used so 

 as to coincide with their degrees of virulence. In other words, 

 in order to test the virulence of the poison, corresponding 

 injections were made into two healthy rabbits, as each day 

 passed by. The results showed that the marrow which wa» 

 used on each of the days, July 6th, 7th, 8th, 9ih, and 10th was 

 not virulent, because the rabbits inoculated with it did not ga 

 mad. The marrows, however, of the next six days were all 

 virulent. For instance, the rabbits inoculated on July 15th 

 and 16th went down with rabies after a period of incubation of 

 seven days, those inoculated on July 12th and ISth after eight 

 days, and those inoculated on July 11th after fifteen days. Hence 

 it was quite clear that, during at least the last two days of his 

 treatment, Joseph Meister had been inoculated with the most 

 virulent virus — namely, that of the dog reinforced by a number 

 of transmissions from rabbit to rabbit, and one which com- 

 municates rabies to dogs after nine or ten days' incubation. In 

 fact, when the stage of immunity is reached, the strongest virus 

 can be inoculated even in large quantities. It was evident that 

 Joseph Meister escaped not only the hydrophobia which his 

 wounds would doubtless have developed, but also that with 

 which he had been inoculated in order to verify the immunity 

 due to the treatment. A very virulent inoculation at the end 



