DISEASES OF THE OX AND SHEEP. 355 



The sub-cultures of the special organism obtained from the 

 cases of human scarlatina are identical in all respects with those 

 obtained from the Hendon cows. In plate cultivation they 

 appear after three, five, or six days as minute greyish-white, 

 translucent circular colonies, not larger than the point of a pin. 

 They only enlarge slowly, and as a rule they take weeks and 

 months to reach a size larger than the head of a medium-sized 

 pin. They are then slightly thicker in the central than at the 

 marginal portion. 



On the surface of solid alkaline nutritive gelatine, of solid 

 blood serum, of solid alkaline Agar-Agar mixtures, the growth 

 is a greyish translucent film made up of isolated translucent 

 greyish circular dots. 



After some weeks or months the film is still thin, translucent, 

 greyish. The marginal dots have become much larger and 

 flatter than those in the middle parts. The former are not 

 quite circular, but more or less irregular, and in old cultivations 

 they are fringed and serrate. 



In alkaline broth or alkaline broth peptone the growth forms 

 •whitish or greyish-white fluflfy or loose masses at the bottom of 

 the tube. In milk the organism grows fairly well, and turns the 

 milk at first thick, then quite solid. Sometimes this occurs 

 Already after two or three days' incubation at 37^ C.^ sometimes 

 a little later. 



The observed characters of the micrococcus, which is present in 

 cases of human scarlatina and in the Hendon cow disease, point 

 to the fact that it is morphologically distinct from any other 

 known micrococcus, and that it has a definite mode of existence. 

 In sections of the tissues taken from a young girl, aged two and 

 a half years, who died of scarlet fever, micrococci were found 

 e.g. in the cervical lymph glands, in lymph spaces, and in small 

 blood-vessels, in the inflamed glomeruli of the kidney, and in the 

 ■small blood-vessels of the enormously engorged lung. Exami- 

 nation of the lung- tissue in three instances revealed that many 

 lobules were enormously congested, the capillaries of the alveoli 

 being much distended by and filled with blood, while in many 

 alveoli blood was seen to be extravasated, the epithelial cells of 

 these and neighbouring alveoli being detached. Dr. Klein also 

 •examined some old sections through the skin of patients who 

 had suff"ered from scarlatina. They were made and mounted in 



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