IQQ THE DISEASES OF DOMESTIC ANIIIALS. 



his stable, both declared this and all the horses in the stable free 

 from any suspicion of glanders. 



Three inoculative experiments were made with the nasal dis- 

 charge, by saturating threads in the same, and drawing the latter 

 through the cutis of a live rabbit's ear. All three gave negative 

 results. 



Haubuer (of Dresden) introduced the (at times valuable) idea 

 of trepanning the sinuses of the head in case glanders is suspected, 

 which will frequently lead to the discovery of the disease. 



It was done in this case this ; " the sinus Highmori contained a 

 moderate amount of muco-purulent secretion, the mucosa of both 

 divisions was somewhat tliickened, hyperaemic, and had a tense but 

 jperfectly smooth feeling. Not a single sign of unevenness could 

 he distinguished. All this seemed to justify the conjecture that in 

 this case we had only to do with a case of chronic catarrh of the 

 sinuses of the head." 



The cavity was treated by injection of a two-per-cent carbolic- 

 acid solution twice a day ; the same flowing out of the left nostril 

 indicated that the opening was still free. 



On the day following the operation a rise in temperature took 

 place, 39'1° C. ; jDulse 56, which again disappeared in time. 



" From the seventh to the tenth day after trepanning the head 

 the intermaxillary glands became very much swollen, but neither 

 abscess formation nor resolution in any degree took place." 



" On the IJrth of May the temperature again increased and 

 continued augmented until the animal was killed. In the mean time 

 the trepan-wound healed completely, and was entirely closed on the 

 22d of May." 



Autopsy by Bollinger, May 28th : 



"Extensive nasal and pulmonary glanders. In the left sinus 

 Highmori (a cavity of the head) a considerable quantity of yellow- 

 ish, thick, viscid, purulent material ; the mucosa having a swollen, 

 uneven nature, clouded with occasional hard neoplasmata (nodes) 

 projecting above its surface ; the infiltration common to glanders to 

 be seen at places. The mucosa of the sinus Highmori dextra 

 (right cavity of skull) presented nothing abnormal, aside from a 

 slight catarrhal swelling." 



In the above, we see that all diagnostic assistance failed to dis- 

 cover the disease. Even the trepan-wound healed normally, and 

 not with long-continued ulceration, as is frequently the case in 

 glanders, and yet the disease loas jpresent. 



We have seen that three inoculative experiments with the dis- 



