THE nORSE. 195 



in slow developiiHMit, the connective tissue prevails. The dissolu- 

 tion is liiistened ur retarded by the same. In slow development, the 

 vascularization is less marked than in rapid. AVherever the pro- 

 cesses of ^lundei-s are present, there may be found the tubercles, al- 

 though the luniks are the favorite seat. They are sometimes present 

 in great numbers, and at others it is very hard to find even solitary 

 examples. 



AVhy the tubercles in the lungs have so little tendency to break 

 down, and those in the nasal mucosa are so prone thereto, must be 

 sought in two circumstances : 



1. Their development is far slower in the lungs. 



2. The matrix is different. 



Those in the lungs are absolutely from a connective-tissue 

 matrix, while those in any mucosa are from a far less consistent 

 matrix. 



At any rate, they occur in the nasal mucosa ranch more as 

 they develop in the lunnan lung, that is, en masse, which, on ac- 

 count of their transient character, accounts for the tendency to 

 breaking down, and here they seem also to have the infectious char- 

 acter of the human tubercle, new ones springing up in immediate 

 proximity to antecedent ones, which gives to the ulcerated surfaces 

 thus caused their rodent or extending characters. 



The development of tubercles in the sinuses of the head does 

 not occur to any such degree as in the mucosa proper to the nasal 

 cavities ; the nodes, or neoplasmatic productions which we find here, 

 have a different character, to which we shall again refer. 



In farcy, the tubercles lie chiefly in the cutis, although they also 

 develop in the subcutaneous cellidar tissue, and frequently attain 

 considerable size. 



" Histologically, the tubercles of glanders arc exactly alike, 

 whether we find them in the lungs, nose, or cutis. In a fresh con- 

 dition they are more or less soft, transparent, and of a pearl-gray 

 color. In this condition they each have an individual central ves- 

 sel, as may be seen by injected lung specimens." 



Do those of the other localities have this central vessel ? 



" In the examination of these nodes, we may often find at the 

 center a hemorrhagic point, which probably proceeds from this 

 vessel. 



" They may continue for a long time in the above condition. 

 "When newly developed, they are immediately limited by healthy 

 lung-tissue; later they become a special limiting membrane of con- 

 nective tissue. They are frequently surrounded by a circle of con- 



