206 THE DISEASES OF DOMESTIC AA^IMALS. 



Incubation. — The incubatory period is from three to five days ; 

 sometimes extending to fourteen days or three weeks. 



Course. — The disease assumes either an acute, subacute, or chronic 



form. 



Acute Glanders. 



Of twenty-eight cases, of which but one ended fatally, the aver- 

 age duration, aside from the period of incubation, was 16*5 days. 

 Cases of seven to eight days' duration are rare ; in general, it lasts 

 two to three weeks, sometimes four. 



The introductory phenomena are frequently a general feeling of 

 disturbance, weakness, headache, shivering, often combined with 

 uncertain pains in the extremities, especially in the muscles and 

 joints. 



If a trauma (wounds) formed the atrium of the inficiens, we may 

 remark on the locus infectionis hypersemia and inflammation of 

 the parts ; swelling and inflammation of the lymphatics. In rare 

 cases the disease begins with shivering. When the pains are in- 

 tense and intermittent or continued, fever is present. The ulcers 

 increase, the edges and base acquire an evil appearance, the ulcer 

 frequently a chancrous, rodent character. "When the wound is upon 

 a finger, the whole arm may be the seat of an erysipelatous or phleg- 

 monous inflammation, which is often complicated with pustular or 

 ulcerous eruptions. The constitutional disturbances increase at the 

 same time : the patient loses appetite ; the evacuations are retarded ; 

 the weakness increases ; the pains in the muscles and joints become 

 more intense, and the fever augments. 



When the anamnesis is wanting, and when the infection has 

 taken place from a volatile inficiens, or when all signs of outward 

 infection fail, the disease might often be mistaken for typhus. As 

 the disease progresses, reddish spots appear on the cutis, which trans- 

 form into pustules resembling those of variola or pemphigus. These 

 pustules often appear in great numbers, and are of varying dimensions. 

 They frequently coalesce and form ulcers, giving off an offensive 

 odor. Large ulcers often develop on the extremities, which extend 

 to the sinews and bones. These cutaneous affections are frequently 

 so extensive as to leave scarcely any part of the body uncomplicated. 

 Sometimes the joints become tumefied with fluctuating swellings. 

 At others these eruptions appear within twenty-four or forty-eight 

 hours ; again, only within two, three, or four weeks, after the ap- 

 pearance of nasal catarrh, tumefaction of the muscles, pain, etc. 



The mucosae, particularly of the nose, are frequently the seat of 

 inflammatory and ulcerative processes. When the nose is compli- 



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