CLINICAL EVIDENCE OF VALUE OF SERUM 431 



treated hogs left as checks manifested undoubted symptoms of 

 hog-cholera, and on postmortem examinations showed the usual 

 lesions of the disease. 



In making the experimental test on this farm, 51 of the spring 

 shoats, weighing from 35 to 50 pounds, were selected for the 

 purpose. Two-thirds of this number, or 34, were injected with 

 serum, each one receiving 20 c.c, and the remaining 17 were 

 left as check animals. Two old sows and one large boar were 

 also treated, each receiving 40 c.c. of the serum. These 2 old 

 sows had young litters of late summer pigs which were left un- 

 treated. There were a few other summer shoats and spring pigs 

 on the premises, which also were left untreated. 



The results in this experiment were most conclusive and en- 

 couraging as a demonstration of the efficiency of serum in check- 

 ing the spread of cholera. Of the 34 shoats which were treated, 6 

 became sick soon after being treated and died. These animals, 

 however, were undoubtedly already sick at the time the treat- 

 ment was administered, and if the temperatures were available 

 they would probably show that all of those that died were running 

 a high temperature at the time of injection. The remaining 

 28 of the treated shoats continued well and passed through the 

 outbreak in healthy and thrifty condition. 



Of the 17 hogs left untreated as checks, but 2 survived. 

 A very marked difference, indeed, between the percentage of 

 loss in those untreated and in those which were treated. The 

 2 old sows which were treated passed along without showing 

 any symptoms of the disease. The boar showed evidences of 

 sickness, but finally recovered. All the summer and spring pigs 

 which were left as checks died, as did also the litters of the 2 

 sows. It will be remembered that these 2 sows received treat- 

 ment, but the pigs did not. 



From the results which we have from this experiment it 

 would seem very likely that had the entire 51 animals selected for 

 the test been injected, the total loss would not have been over 10. 

 This is in decided contrast to the results of the disease on Farm. 

 Number One, where the disease ran its course untreated with a 

 loss of over 90 out of a total herd of 100. The death-rate on this 

 first farm, as well as the high percentage of deaths among the 



