CLINICAL EVIDENCE OF VALUE OF SERUM 439 



posed to the germs of cholera that they were all sick at the time 

 of injection, and a hog sick from cholera is usually regarded as a 

 dead hog. If temperatures had been taken for this experiment they 

 would very likely have shown that every one of the treated shoats 

 was sick, and, on account of their close association, the old hogs 

 would also, no doubt, have been found to be coming down with 

 cholera. 



Final returns, however, show that of the treated pigs, 12 sur- 

 vived and 17 died. Of the 14 checks, 11 died and 3 lived, one of 

 which was so stunted in growth as to be worthless. All of the old 

 sows survived, and not one of them showed the shghtest evidence 

 of being sick, even after being turned into the disease-infected feed 

 lot. 



This report should prove quite instructive. The use of as small 

 a dose of serum as 20 c.c. in these sick pigs saved over 40 per cent, 

 of them. If temperatures had been taken, and larger doses of 

 serum given, it is quite probable that even a much larger number 

 would have survived. The figures, even as they stand, when 

 compared with the results in the untreated checks, leave a very 

 favorable showing for the use of serum even in the presence of 

 the disease. 



Results in the case of the treated sows are most interesting. 

 These old hogs had almost certainly been exposed to a certain 

 degree at the time of injection. Cholera had not got much head- 

 way in their bodies at that time, and the use of the serum promptly 

 checked the inroads of the germs and saved them from any loss. 

 In these sows both the serum-alone and the serum-simultaneous 

 methods were used. In both cases the results were excellent. 

 In many of these old hogs cholera germs were already present, and 

 in such cases the injection of the single treatment stimulated pro- 

 duction of germ-fighting bodies by the cells of the body and a 

 permanent protection was developed. 



The most interesting part of this experiment is contained in the 

 last part of the report, wherein it is shown that the sows, when 

 turned into the diseased lots, did not become sick. At the time the 

 sows were placed in the infected lot two weeks had elapsed since 

 they were given treatment. The protection given by the single as 

 well as that derived from the double injection was active at this 



