CLINICAL EVIDENCE OF VALUE OF SERUM 451 



This herd gives a very good example of what may be expected 

 from the simultaneous method of treatment. 



Here a herd of 20 shoats were treated by the serum-virus 

 method, and a month later passed through an outbreak of the 

 disease in which they remained in the same feed lot with sick 

 animals, and not one of them were lost. All of the untreated 

 animals that remained at the time of the outbreak became sick, 

 and all but one died. The treated animals did not even become 

 sick, and none of them were lost. Had this entire herd been treated 

 by the double method there would have been no loss whatever. 



It is also worthy of note that very small doses of serum were 

 used in this herd, as compared with the body-weight of the animals 

 and the amount of virus blood given. Yet with a powerful serum 

 the results were good even in this small dosage. I would not, 

 however, recommend the use of this small dose of serum in doing 

 simultaneous work as a regular practice. Rather use a little more 

 than is necessary than not enough. 



The question might arise as to whether or not the untreated 

 hogs in this herd were infected from the treated animals by passage 

 of the virus blood through their bodies and out into the feed lots 

 with the manure and urine. I think not. The length of time which 

 passed between the date of this injection and the date of the 

 development of the disease in the untreated animals was too long 

 for infection to have taken place in this way. While cholera 

 infection may be slow in developing in some cases, it is rarely 

 if ever so long delayed as thirty days. 



The probabilities are much stronger that the infection in this 

 case took place through virus of the disease being brought upon 

 the place later on from some neighboring farm where the disease 

 was present, as there was a large amount of cholera in this part 

 of Grant Township at the time. 



This experiment also gives an example of the advantage of 

 the serum-simultaneous treatment over the serum-alone method. 

 Had the serum-alone method been used in this case the protective 

 power against the disease would have been run out before the out- 

 break really took place, and the treated hogs would, no doubt, have 

 taken the disease as well as the untreated. By use of the double 

 method protection is secured not only against the immediate 



