472 DISEASES OF SWINE 



was necessary to leave nearly 50 of the animals untreated to 

 serve as checks. 



In about one week after the administration of the treatment 

 the old sow began to show symptoms of disease. At about the 

 same time 2 of the injected shoats began to develop a diarrhea 

 and showed a loss of appetite. The old sow died on October 

 28th, just ten days after treatment was given, and when the body 

 was opened up after death all the changes typical of hog-cholera 

 were seen. There was some redness, over the skin, especially on 

 the skin of the belly and neck, bright red spots on the surface 

 of the lungs, spleen very much enlarged and dark in color, liver 

 was congested, kidneys swollen, and showing the usual turkey- 

 egg spotting, bright red color of the lining membrane of the large 

 bowels, and general enlargement and softening of the lymphatic 

 glands. 



On the same date that this animal died the entire herd was 

 retreated, this time with serum alone. At this time not only those 

 animals which had been treated at the first visit, but also the 

 50 other animals on the farm were injected. In the case of the 



2 sick shoats the dose of serum given was 60 c.c. to each one. 

 The other animals in the herd received from 20 to 30 c.c. each. 



The results which followed this second injection with the serum 

 alone were most pleasing. The 2 sick shoats quickly improved 

 and went on to recovery. No more of the herd became sick, and 

 the threatened outbreak was promptly stopped. 



The results in this herd would seem to show that the old sow 

 and the 2 shoats became sick as a result of the simultaneous 

 treatment. In my opinion, the cause for this outbreak in these 



3 animals was the fact that the dose of virus given was over- 

 large and the dose of serum was rather low as compared to the 

 doses we now recommend. There is also the possibility that these 

 animals were especially susceptible to hog-cholera, and on this 

 account developed the disease under conditions where other 

 animals would not have been effected. This only serves to im- 

 press upon us the fact that we must not get careless in any way 

 in handling this double method of treatment. We must especially 

 use care in regulating the dosage in order that we may always 

 play on the safe side. It is better to give a little too much serum 



