264 Wound Infection ; Suppuration 



ceolatus, 6 cases; gas bacillus (B. aerogenes capsulatus), 

 three times alone and twice combined with Bacillus coli 

 communis; the gonococcus, anthrax bacillus, Bacillus pro- 

 teus, the last combined with Bacillus coli; Bacillus coli 

 alone; a peculiar capsulated bacillus, and an unidentified 

 coccus." 



It is interesting to observe in how many cases the 

 streptococcus was. present. All the streptococci found 

 may not have been Streptococcus pyogenes, but for conve- 

 nience in his statistics they were regarded as such. 



The presence of streptococci in the blood in scarlatina has 

 been observed in 30 cases by Crooke, by Frankel and Tren- 

 denburg, Raskin, Leubarth, Kurth, and Babes. In n cases 

 of scarlatina studied by Wright * a general streptococcus 

 infection occurred in 4, a pneumococcus infection in i , and a 

 mixed infection of pyogenic cocci in i . 



Lemoine f found streptococci in the blood during life in 2 

 out of 33 cases of scarlet fever studied. Pearce J studied 17 

 cases of scarlatina and found streptococci in the heart's 

 blood and liver in 4, in the spleen in 2, in the kidney in 5 

 cases. In 2 of the cases Staphylococcus pyogenes aureus 

 was associated with the streptococcus. 



The streptococcus is the most common organism found in 

 the suppurative sequelae of scarlatina, frequently occurring 

 alone; sometimes with the staphylococci ; sometimes with 

 the pneumococci. Councilman found secondary infection 

 by the streptococcus more widespread in variola than in 

 any other disease. 



Virulence. Streptococcus pyogenes is very variable in its 

 virulence for the lower animals, and seems to be most 

 pathogenic for that species of animal from which it has been 

 isolated. If isolated from man, it may not be virulent for 

 mice, guinea-pigs, or rabbits, and -vice -versa. If the cultures 

 be of moderate virulence and the ear of a rabbit be carefully 

 inoculated with a small quantity of a pure culture, local 

 erysipelas usually results, the disturbance passing away in a 

 few days and the animal recovering. 



If, however, the streptococcus be highly virulent, the rab- 

 bit dies of general septicemia in from twenty-four hours to 

 six days. The cocci may then be found in large numbers 



*" Boston Med. and Surg Jour.," March 21, 1895. 

 f'Bull. et Mem. Soc. d'Hop. de Paris," 1896, 3 s., xm. 

 J"Jour. Boston Soc. of Med. Sci.," March, 1898. 



