Lesions 327 



many nuclei as there were component cells. It may be 

 that the nuclei of the giant-cells multiply by karyokinesis 

 after the protoplasmic coalescence, but only one observer, 

 Baumgarten, has found signs of this in giant-cells. 



Different writers hold varying opinions concerning the 

 formation and office of the giant-cells. Thus, while I* re- 

 gard them as degenerative formations, and unimportant 



& . 



**$* r; r C-"-.~ 



Fig. 97. Miliary tubercle of the testicle: a, Zone of epithelioid cells 

 and leukocytes; 6, area of coagulation-necrosis; c, giant-cell with its 

 processes; peripherally arranged nuclei and necrotic center; d, semin- 

 iferous tubule (Cameron, in " International Text-book of Surgery"). 



entities, there are many who believe with Metschnikoff 

 that they are enormous phagocytes. Hektoenf believes 

 that they are active bodies from which cells split off. 



Giant -cells are not always formed in tubercles, as the 



* "International Medical Magazine," vol. i, No. 10, 1892; vol m, 

 No. 2, 1894. 



t "Journal of Experimental Medicine," vol. in, 1898, p. 21. 



