34-O Tuberculosis 



Antitubercle Serums. Tizzoni and Centanni,* Bern- 

 helm,! Paquin,{ and others have experimented in various 

 ways, hoping that the principles of serum therapy might 

 apply to tuberculosis. Nothing has, however, been achieved. 

 Maragliano's antitubercle serum has been used in a very 

 large number of cases in human medicine, and many cures 

 as well as improvements are reported. Behring || comments 

 upon it by saying that "Maragliano's tubercle antitoxin 

 contains no antitoxin." 



Babes and Proca,** in an experimental research upon the 

 action of an antituberculous serum, claim to have observed 

 a decided specific action. 



Maffucci and di Vesteaff found that by injecting guinea- 

 pigs with serum from sheep immunized by injections first 

 of dead, then of living cultures of tubercle bacilli, although 

 no cures were brought about, the vitality of the animals 

 was maintained longer. Unprotected animals died in fifty 

 to fifty-three days; those injected after infection, seventy- 

 four days; and those injected before infection, ninety-one 

 days. 



The author J{ made a study of antituberculin, prepared by 

 injecting donkeys for a long period with increasing doses 

 of tuberculin. Experiments upon guinea-pigs showed that 

 the serum was powerless to immunize against the tubercle 

 bacillus, or to cure established tuberculosis. The serum, 

 however, had the power of annulling the effects of tuber- 

 culin upon tuberculous animals. 



De Schweinitz injected cows and horses with increas- 

 ing quantities of bouillon cultures of a greatly attenuated 

 tubercle bacillus, and thought he found the serum capable 

 of rendering guinea-pigs immune. 



Fisch || || immunized a horse against tuberculin-R, hoping 



*" Centralbl. f. Bakt.," etc., Bd. xi, p. 82. 



t" Centralbl. f. Bakt.," etc., Bd. xv, p. 654. 



J " New York Med. Rec.," 1895. 



" Berliner klin. Wochenschrift," 1895, No. 32. 



|| " Fortschritte der Med.," 1897. 

 **"La Med. Moderne," 1896, p. 37. 

 ft " Centralbl. f. Bakt.," etc., 1896, Bd. xix, p. 208. 

 Jf'Jour. Amer. Med. Assoc.," Aug. 21, 1897 



" Centralbl. f. Bakt. und Parasitenk.," Sept. 15, 1897, Bd. xxn, 

 Nos. 8 and 9. 



|| || "Jour. Amer. Med. Assoc.," Oct. 30, 1897. 



