Virulence Immunity 371 



mucous surfaces, the breaking down of the nodules per- 

 mitting the softened material to escape. At times the 

 lesions heal with the formation of stellate scars. 



Baumgarten * regarded the histologic lesions of glanders 

 as much like those of the tubercle. He first saw epithe- 

 lioid cells accumulate, followed by the invasion of leuko- 

 cytes. Tedescm't was not able to confirm Baumgarten 's 

 work, but found the primary change to be necrosis of the 

 affected tissue followed by invasion of leukocytes. The 

 observations of Wrightf are in accord with those of Tedeschi. 

 He first saw a marked degeneration of the tissue, and then 

 an inflammatory exudation amounting in some cases to 

 actual suppuration. 



Virulence. The organism is said to lose virulence if 

 cultivated for many generations upon artificial media. 

 While this is true, attempts to attenuate fresh cultures by 

 heat, etc., have usually failed. 



Immunity. Leo has pointed out that white rats, which 

 are immune to the disease, may be made susceptible by 

 feeding with phloridzin and causing glycosuria. 



Babes has asserted that the injection of mallein into sus- 

 ceptible animals will immunize them against glanders. 

 Some observers claim to have seen good therapeutic results 

 follow the repeated injection of mallein in small doses. 

 Others, as Chenot and Picq, find blood-serum from im- 

 mune animals like the ox to be curative when injected 

 into guinea-pigs infected with glanders. 



Pseudoglanders Bacillus. A bacillus similar in its tinc- 

 torial and cultural peculiarities, but not pathogenic for mice, 

 guinea-pigs, or rabbits, was isolated from pus by Selter. || The 

 organism was called the pseudoglanders bacillus. A similar 

 one had previously been described by Babes.** 



* " Pathologische Mykologie," Braunschweig, 1890. 

 t "Ziegler's " Beitragez. path. Anat.," Bd. xin, 1893. 

 t "Journal of Experimental Medicine," vol. i, No. 4, p. 577. 

 " Compte-rendu de la Soc. de Biol.," March 26, 1892. 

 || "Centralbl. f. Bakt.," etc., Feb. 18, 1902, xxxv, 5, p. 529. 

 ** " Archiv. de med. exp. et d'anat. path.," 1891. 



