68 PATHOGENIC BACTERIA. 



with a temperature equally high, readily falls a victim 

 to anthrax without a cold bath. 



(b) By altering the chemistry of the blood by changing 

 the diet or by hypodermic injection. Leo found that 

 when white rats were injected with or fed upon phlorid- 

 zin an artificial glycosuria resulted which destroyed their 

 natural resistance to anthrax. Hankin found that rats, 

 which possess considerable immunity to anthrax, could 

 be made susceptible by a diet of bread. Platania suc- 

 ceeded in producing anthrax in dogs, frogs, and pigeons, 

 naturally immune, by subjecting them to the influence 

 of curare, chloral, and alcohol. 



(c) By diminishing the strength of the animal. Roger 

 by compelling white rats to turn a revolving wheel until 

 exhausted destroyed their immunity to anthrax. 



(d) By removing the spleen (?). A large number of 

 experiments have been performed by various investi- 

 gators to show that the removal of the spleen does or 

 does not affect immunity. From their work it seems 

 proper to conclude that the spleen has little, if any, in- 

 fluence upon the vital resistance to disease. 



I. Bardach, 1 Righi, 2 and Montuori 3 seem to have shown 

 that the removal of the spleen lessens the ability of the 

 organism to combat the infections. 



II. Blumenreich and Jacoby, 4 on the contrary, found 

 that the removal of the spleen was followed by a hyper- 

 leucocytosis, an increase in the bactericidal power of the 

 blood, and consequent increase of immunity. 



III. Milkinow-Raswedenow 5 found that the removal of 

 the spleen was a weakening factor in the immunization 

 of animals. The spleen itself, however, was of little 

 importance in combating the micro-organismal infections. 



Kurlow 6 concluded from his experiments that the in- 



1 Ann.Je r/nst. Pastfitr, 1889, No. 2, p. 577, and 1891, No. I, p. 40. 



AV/o/w,; .\/f,/i,-a t 1893, PP- 17, 171- 



Ibid., Feb., 1893, 17, 1 8. Btrlin. klin. Wochenschrift, May 24, 1897. 

 6 Zeitschrift ?, 1896, xxi., 3. 



Archn .'. INS.,, i;,i. ix., p. 450. 



