1 96 PA THOGENIC BA CTERIA . 



granular precipitate, above which the liquid remains 

 clear. 



When injected into animals Fehleisen's coccus behaves 

 exactly like the Streptococcus pyogenes. 



Observation has shown that dire results may follow the 

 entrance of this organism into exposed wounds, and that 

 it causes not only local suppuration, but sometimes a 

 general infection. 



The empiric experience that the occasional accidental 

 infection of malignant tumors with erysipelas cocci was 

 followed by sloughing and subsequent disappearance of 

 the tumor, suggested inoculation with the Streptococcus 

 erysipelatis as a therapeutic measure. The dangerous 

 character of the remedy, however, caused many to re- 

 frain from its use, for when one inoculated the living 

 erysipelas germs into the tissues he never could estimate 

 the exact amount of disturbance that would follow. The 

 difficulty seems to have been overcome by Coley, who 

 recommends the toxin instead of the living coccus for 

 injection. A virulent culture is obtained, inoculated 

 into small flasks of slightly acid bouillon, allowed to 

 grow for three weeks, then reinoculated with Bacillus 

 prodigiosus, allowed to grow for ten or twelve days at 

 the room-temperature, well shaken up, poured into bottles 

 of about f 3ss capacity, and rendered perfectly sterile by an 

 exposure to from 50-60 C. for an hour. It is claimed 

 that the combined toxins of erysipelas and prodigiosus 

 are much stronger than the simple erysipelas toxin. The 

 best effects are found in cases of sarcoma, where the 

 toxin causes a rapid necrosis of the tumor tissue, which 

 can be scraped out with an appropriate instrument. 

 Numerous cases are on record in which this treatment 

 has been most efficacious; but, although Coley recom- 

 mends it and Czerny still upholds it, the majority of sur- 

 geons have failed to secure the desired results. 



Recently (1895) considerable attention has been be- 

 stowed upon the anti-streptococcus scrum of Marmorek, 

 which is said to act specifically upon cases of strepto- 



