376 



PATHOGENIC BACTERIA. 



When ingested the resisting power of the bacillus per- 

 mits it to pass uninjured through the acid secretions of 

 the stomach and to enter the intestine, where the chief 

 local disturbances are set up. 



The bacilli enter the solitary glands and Peyer's patches, 

 and multiply slowly during the one to three weeks of the 

 incubation of the disease. The immediate result of their 

 residence in these lymphatic structures is increase in the 

 number of cells, and ultimately the necrosis and slotigh- 



FIG. 108. Intestinal perforation in typhoid fever. Observe the threads of 

 tissue obstructing the opening. (Museum of the Pennsylvania Hospital.) 

 (Keen, Surgical Complications and Sequels of Tvphoid Fever.} 



ing which cause the typical post-mortem lesion (Fig. 108). 

 From the intestinal lymphatics the bacilli pass, in all 

 probability, to the mesenteric glands, which become en- 

 larged and softened, and finally extend to the spleen and 

 liver, and sometimes to the kidneys. The growth of the 

 bacilli in the kidneys causes the albuminuria of the dis- 

 ease. Sometimes under these conditions the bacilli may 



