438 PATHOGENIC BACTERIA. 



Kitasato found that mice, rats, guinea-pigs, and rabbits 

 are all susceptible; pigeons are immune. Julian Haw- 

 thorne, in his paper in the Cosmopolitan, speaks of hav- 

 ing seen cats and dogs dying of the disease, but no men- 

 tion is made of these animals in the scientific papers I 

 have read. When blood, lymphatic pulp, or pure cul- 

 tures are inoculated into them, the animals become ill in 

 from one to two days, according to their size. Their eyes 

 become watery, they begin to show disinclination to take 

 food or to make any bodily effort, the temperature rises 

 to 41.5 C., they remain quietly in a corner of the cage, 

 and die with convulsive symptoms in from two to five 

 days. 



Devell * has found that frogs are susceptible to the dis- 

 ease. 



Wyssokowitz and Zabolotmy 2 found monkeys to be 

 highly susceptible to plague, especially when inoculated 

 subcutaneously. When so small an inoculation was 

 made as a puncture with a pin dipped in a culture of the 

 bacillus, the puncture being made in the palm of the 

 hand or sole of the foot, the monkeys always died in 

 from three to seven days. In these cases the local edema 

 observed by Yersin did not occur. They point out the 

 interest attaching to infection through so insignificant a 

 wound and without local lesions. 



According to Yersin, an infiltration or watery edema 

 can be observed in a few hours about the point of inocula- 

 tion. The autopsy shows the infiltration to be made up 

 of a yellowish gelatinous exudation. The spleen and 

 liver are enlarged, the former often presenting an appear- 

 ance much like an eruption of iniliary tubercles. Some- 

 times there is universal swelling of the lymphatic glands. 

 Bacilli are found in the blood and in all the internal 

 organs. Very often there are eruptions during life, and 

 upon the inner abdominal walls there are petechiae and 

 occasional hemorrhages. The intestine is hyperemic, the 



1 Ctntralbl.f. Rakt. u. Parasitenk., Oct. 12, 1897. 



* Ann. df r fnst. Pasteur, Aug. 25, 1897, xi., 8, p. 665. 



