450 PATHOGENIC BACTERIA. 



A. Catanni, Jr. 1 trephined rabbits and injected influ- 

 enza toxin into their brains, at the same time trephining 

 control-animals, into some of whose brains he injected 

 water. The results were that animals thus receiving 

 0.5-1 mgr. of the living culture constantly died in 

 twenty-four hours with all the nervous symptoms of the 

 disease, dyspnea, paralysis beginning in the posterior 

 extremities and extending over the whole body, clonic 

 convulsions, stiffness of the neck, etc. Control-animals 

 injected with a variety of pathogenic bacteria in the 

 same manner never manifested similar symptoms. The 

 virulence of the bacillus was also observed to increase 

 rapidly when transplanted from brain to brain. 



1 Zeitschrift fitr Hygiene, etc., Bd. xxiii., 1896. 



