THE PRODUCTS OF TRYPTIG DIGESTION. 197 



tion. On acidifying with sulphuric acid, however, as in the study 

 of peptic digestion, it may happen that a turbidity appears, which 

 is probably due to the presence of Neumeister's antideutero-albumose, 

 resulting from anti-albumid. The final filtrate contains polypeptid 

 and ammo-acids in the free state. 



Reactions of the Individual Albumoses. 



Whether or not the different albumoses which are formed during 

 the process of digestion are qualitatively the same, irrespective of 

 their origin, is not known, but it is likely that certain differences 

 exist. Quantitative differences also undoubtedly occur, as is suggested 

 a priori by the varying amounts of the individual end-products 

 which can be obtained on hydrolysis. The following account of the 

 individual albumoses is largely based on a study of the fibrinoses. 



Hetero-albumose. Hetero-albumose is more closely related to the 

 original albuminous molecule than any other albumose. It is but 

 little soluble in water and does not dialyze in neutral solution. On 

 heating a fairly concentrated solution in the presence of a moderate 

 amount of salt, partial coagulation occurs between 55 and 60 C. ; 

 on further heating, partial solution takes place. On standing 

 hetero-albumose becomes insoluble in part (Kiihne's dysalbumose) ; 

 but upon the addition of a small amount of soda redissolution occurs 

 and hetero-albumose again results. The same occurs, when the heat 

 coagulum is dissolved in dilute hydrochloric acid. A denaturiza- 

 tion thus does not occur. In acid solution hetero-albumose is pre- 

 cipitated in toto on half-saturation with sodium chloride. Its limits 

 of precipitation for ammonium sulphate in neutral solution are 2.6 

 and 4.4. Alcohol precipitates it very readily ; it is insoluble in the 

 presence of 32 per cent. With the usual albumin precipitants 

 hetero-albumose shows a typical albumose reaction (page 63). Its 

 elementary composition is = 55.12, H = 6.61, N = 17.P8, 

 S = 1.22, O= 19.07. It contains no carbohydrate group, ana 

 possibly also no tyrosin or tryptophan radicle ; it accordingly does 

 not give the Molisch reaction or that of Adamkiewicz. The sub- 

 stance is an anti-body in the sense of Kiihne, and is accordingly 

 related to Kiihne's anti-albumid and the an ti peptone group. On 

 further digestion it yields deutero-albumoses of the A and B group, 

 traces of deutero-albumose C, and a considerable amount of Pick's 

 peptone B. On hydrolysis it yields much leucin and glycocoll and 

 39 per cent, of the total nitrogen in basic form ; it also contains the 

 phenyl-alanin complex. 



Proto-albumose. Proto-albumose in its physical behavior shows 

 that it stands further removed from the original albuminous mole- 

 cule than hetero-albumose. It is quite readily soluble in water and 

 diffuses to some extent through vegetable parchment. It is not 

 coagulated by heat. With nitric acid only partial precipitation 

 occurs. The alkaloidal reagents cause the precipitation of proto- 



