8 4 THE CHEMISTR V OF THE TISSUES AND ORGANS. 
and then dried it and extracted it with water. Proteoses and peptone 
went into solution, the other proteids having heen coagulated. It is pro- 
bable that some of the symptoms which accompany the suppurative pro- 
cess is produced by the entrance of these substances into the circulation. 1 
There is little to add concerning the other constituents of pus cells. 
The large increase of fat, lecithin, and cholesterin confirms the fact of 
fatty degeneration, evident to the microscope ; free fatty acids may even 
be found in old pus, forming crystalline deposits. 
Glycogen can often be demonstrated in pus corpuscles miero- 
chemically by the use of iodine ; 2 Salomon 3 separated it from the cells 
in appreciable quantities. 
Pigments (pyocyanin, pyoxanthose) are frequently found in pus, and 
are produced by chromogenic bacteria (Fordos, Liicke, Fitz, Kunz, 
Babes). 4 
The proteids of red marroiv cells. — In the lymphatic glands and 
thymus the cells are non-eosinophile ; in the red marrow the cells are 
mostly eosinophile. Sherrington 5 showed that the eosinophile granules 
give microchemicallv the reaction for phosphorus, introduced by Lilienfeld 
and Monti ; 6 the cells themselves were investigated macrochemically by 
J. E. Forrest. 7 The marrow used was obtained from the interior of 
rabbits' femora and horses' ribs. 
His results were very like those obtained from other cellular 
structures. Two proteids only were obtainable in any quantity, these 
were a cell globulin, coagulating at 47°-50°, and a nucleo-proteid. The 
latter contains a high percentage of phosphorus, 8 namely, l - 6. Hemo- 
globin is present in small quantities, and proteose and peptone are absent. 
Epithelium. — Our knowledge of the tissues included under the 
heading epithelium is principally histological. There is no reason to 
suppose that the proteid constituents of the protoplasm and nucleus are 
in any way different from that found in cells generally. 
Mucin is formed in many situations, both in the cells of mucous 
glands and in goblet cells. It is also the principal constituent of the 
cementing material between the cells. 
Munis is the name given to the secretion which owes its sliminess to 
mucin. Mucus also contains epithelial cells, more or less disintegrated, and a 
few leucocytes. It has an alkaline reaction, and contains a certain small pro- 
portion of proteids, extractives, and salts, similar to those of the blood. In 
some cases, the mucinoid material in secretions is really a nucleo-proteid. 
Thus, in the bile of some animals like the ox, there is very little true mucin, 
but the viscidity is almost entirely due to nucleo-proteid ; 9 in human bile, on 
the other hand, the viscid material is mucin, very little nucleo-proteid being 
1 Ott and Collmar, Joum. PJu/siol., Cambridge and London, vol. viii. p. 218 ; Krebl 
and Matthes, Detrfsches Arch. f. klin. Med., Leipzig, 1896, Bd. liv. S. 501 ; Arch.f. exper. 
Path. u. Pharmacol., Leipzig, 1S96, Bd. xxxvi. S. 437. 
2 Ranvier, Progris mid., Paris, 1877, p. 422. 
3 Deutsche. ni"L Wchnschr., Leipzig, 1877, No. 35. 
4 Compt. rend. Acad. d. sc., Paris, 1860, tome li. p. 215 ; Arch. f. klin. Chir., 
Berlin, 1862, Bd. iii. S. 125 ; Quart. Joum. Micr. Sc, London, Jan. 1880, p. 106 ; 
Monatsh. d. Cliem., Wien, Bd. ix. S. 361 ; Compt. rend. Soc. de hiol., Paris, 1889, 
p. 438. 
5 Proc. Boy. Soc. Lcmdon, 1894, Bd. lv. p. 161. 
6 Ztschr.f. physiol. Cliem., Strassburg, 1893, Bd. xvii. S. 410. 
7 Joum. Physiol., Cambridge and London, 1 S 9 4 , vol. xvii. p. 174. 
8 Halliburton, ibid. , 1895, vol. xviii. p. 307. 
;l Paijkull, Ztschr.f. physiol. Ohem., Strassburg. Bd. xii. S. 196. 
