38 



that this requires further corroboration, although he 

 states that he verified his diagnosis by the presence of 

 a form of saccharomyces. His experiments with guinea- 

 pigs were in some cases complicated with glanders, so 

 are not conclusive, but he failed to reproduce the disease 

 in rats, hares, pigs, dogs, and cats. 



Haubert, Delrade, and Wiart's attempts to repro- 

 duce the disease in horses failed. 



Tixier, Delamotte, Chauvrat, and Peuch reproduced 

 the disease in donkeys. 



Nocard reproduced it in horses, mules, and 

 donkeys, but failed in cattle, goats, and guinea-pigs. 



Rivolta and Micellone succeeded in horses, as 

 also did Bassi and Venuta, but they failed in goats. 



Moore appears to have succeeded in a horse and 

 failed in guinea-pigs. 



Lingard carried out experimental inoculations on 

 various species of animals in India, but I am not 

 aware of his final results. 



Personally, I reproduced the disease in horses, 

 mules, and donkeys, but failed in cattle, sheep, goats, 

 and guinea-pigs, all the usual methods of experimental 

 inoculation being resorted to, but the best results were 

 obtained from the inoculation of ordinary wounds. In 

 all cases attempts to reproduce the disease by ingestion 

 were followed by negative results. 



Recently Mettam reproduced the disease in a horse 

 at the Royal Veterinary College of Ireland, Dublin, but 

 also failed in the ox, using the same material. 



The inoculatiojis made by the various investigators 

 of this disease were carried out in the following 

 different methods, viz. : — scarification, artificial inocula- 

 tion of wounds and mucous membranes, subcutaneous 

 inoculations, and by ingestion. All the methods men- 

 tioned, except the latter, appear to have been attended 

 with more or less success in the susceptible species, but 



