38 



The first rabbit inoculated sub dura cerebri with a small quantity 

 of the medulla of the cow first showed symptoms of illness on the 

 eighteenth day following inoculation. Death occurred on the twen- 

 tieth day. 



The rabbit (No. 3) inoculated in the same manner as the first with 

 a pari of the medulla of rabbit No. 1 was taken sick upon the fif- 

 teenth day and died upon the eighteenth. 



There was in the two a difference of three days in the period of 

 incubation, while the time of illness varied a few hours. 



At seven-thirty a. m. July thirty-first No. 2 was found ill, and his 

 cage showed signs of his having been violent sometime during the 

 night. At intervals of a few hours during the day he suffered from 

 convulsions which lasted some minutes. During these he would 

 jump about the cage recklessly and violently, occasionally scratching 

 and tearing the litter wiih his feet. Between the paroxysms he 

 would remain stretched out upon his side or crouched in the corner. 

 At all times he was excitable and the simple approach of a person 

 was sufficient to occasion a convulsion. Death occurred at three- 

 thirty p. M. No post-mortem examinations were made of rabbits 

 Nos. 2 and 3. 



It was the intention to have carried the sub-dural inoculative 

 experiments through several more rabbits, but it was not done on 

 account of the unavoidable absence of the writer at the time of the 

 death of animals Nos. 2 and 3. 



Taking into consideration the symptoms exhibited b}' the cows, 

 the period of incubation and duration, the history of an attack by 

 dogs, the fact that no animals were affected except in herds where 

 they were known to have been attacked or bitten by dogs, the experi- 

 ments with the rabbits in which a shortening of the period of incu- 

 bation occurred as a result of sub-dural injection of parts of the brain 

 tissue of affected animals, we feel that we are justified in sa^nng that 

 this mysterious disease was genuine Kabies. 



I wish to acknowledge tlie kindness of W. C. Eaton, (J. E., for allowing the use of 

 the map used in this bulletin and that of others who have assisted me in various 

 ways. JAMES B. PAIGE, D. V. S. 



