486 INFLUENCE OF FOOD PKESEEVATIVES ON HEALTH. 



Almost one-half is recovered in the case of No. 4. a little over one-half 

 in the case of No. 5, a little less than one-half in the case of No. 6, a 

 little over one-third in the case of No. 7, almost one-half in the case 

 of Nos. 8 and 9, a little over a third in the case of No. 10, and less than 

 one-half in the cases of Nos. 11 and 12. 



The summary for 12 men shows that 44.47 per cent of the salicvlic 

 acid administered was recovered, an average of 443 milligrams out of 

 996. If the correction indicated by the blanks be made, a total average 

 recovery of 46.8 per cent of salicylic acid unchanged is indicated. 

 The balance of the salicylic acid is apparently changed into salicyluric 

 acid or other combination^ or remains stored in the body. 



The difference in composition between salicylic acid and salicyluric 

 acid is shown by the following formula: 



Salicylic acid, C 7 H 6 O 3 =OH.C 6 H 4 .CO 2 H. 



Salicyluric acid, C 9 H 9 NO 4 =-OH.C 6 H 4 .CO.NH.CH 2 .CO 3 H. 



It is stated by most authorities that salicylic acid when administered 

 internally is found in the urine partly as salicyluric acid. This body 

 is separated from salicylic acid by the volatilization process described. 

 The quantities found in our experiments by this method were not 

 weighable. 



DAILY MEDICAL AND CLINICAL NOTES. 



INDIVIDUAL DATA. 



No. l.J. H. S. 



On the first day of the fore period the .subject's weight was 53.45 

 kilograms; temperature, 98.4; pulse, two observations, 76 and 80. 

 His health was excellent and his physical condition without a flaw. 

 No variations of note in physical condition occurred on the succeeding 

 days of the fore period. The temperature on the final day of the fore 

 period, October 28, was 98.2 and 98.6, two observations; the pulse, 

 70 and 80, and the weight 53.36 kilograms. The average weight for 

 the entire fore period was 53.38 kilograms, and the daily variations 

 were small. 



On the first day of the first preservative subperiod (October 29 to 

 November 2) the temperature was a little below the normal, two 

 observations being 98.1 and 97.8, and the pulse 68 and 70 per 

 minute, respectively. The second day the temperature was normal. 

 No marked variation in condition was observed during the first pre- 

 servative subperiod except a slight decrease in weight, the average 

 weight for this period being 53.25 kilograms. 



The second preservative subperiod began on November 3 and closed 

 November 7. The temperature was slightly below the normal on 

 November 4, reaching 97.9 on the first observation and 98.4 on the 

 second. On the 5th the temperature was still slightly below the nor- 



