SALICYLIC ACID AND SALIC YLATES. 487 



mal, but the health of the subject was good. On November 6 No. 1 

 complained of not having his appetite satisfied by his meals and stated 

 that he was hungry, but his health was good. The feeling of lack of 

 sufficient food continued on the following day, and there was a slight 

 increase in the temperature, three observations having been made, 

 registering 98.2, 99.8, and 99, respectively. The rapidity of the 

 pulse was also increased, having registered 82 at 6.20 p. m. There 

 was a continued, though slight, falling off in weight during this sub- 

 period, the average weight being 53.15 kilograms. 



The third preservative subperiod began on November 8 and closed 

 on November 12. On the first day of this subperiod the subject still 

 complained of being hungry. His health was good, but the feeling of 

 hunger was pronounced on the following day, when the subject entered 

 upon his notes, " Don't get enough to eat," and on the following day 

 registered the observation, " Could eat more." The feeling of hunger 

 continued during the whole of the third preservative subperiod. The 

 average weight decreased to 53.05 kilograms. 



The fourth preservative subperiod began on November 13 and closed 

 on the 17th. There was a slight increase of temperature noticed at 

 the second observation on the 13th, the thermometer registering 99.4 

 and the pulse registering 84 beats per minute. The feeling of hunger 

 continued through the fourth subperiod, but no other notable vari- 

 ation in the condition of the subject was observed. The weight 

 throughout this subperiod remained practically constant, the average 

 weight being 53.06 kilograms. 



The fifth preservative subperiod began on November 18 and ended 

 on the 22d. The feeling of hunger still persisted, and on the 19th the 

 subject complained of feeling as though there were a lump in the stom- 

 ach, accompanied by continued belching. His temperature was below 

 the normal, the two observations being 97.7 and 97.4, respectively. 

 The feeling of disturbance in the stomach and of hunger continued on 

 the 20th, but the temperature was restored to normal. On the 21st 

 the patient described himself as feeling uncomfortable in the region 

 of the stomach and still hungry. On the 22d he was very hungry, 

 and the feeling as of a lump in the stomach continued. There was a 

 continued loss of weight during this subperiod, the average for the 

 subperiod being 52.78 kilograms. 



The sixth preservative subperiod began on November 23 and ended 

 on November 27. On the 23d the patient described his symptoms as 

 "Very hungry," with a gnawing feeling in the stomach. The same 

 symptoms were also reported for the 24th and 25th of November. 

 The average weight for the sixth preservative subperiod was 52.62 

 kilograms and that of the entire preservative period 52.99 kilograms. 

 Judged by the daily chart, the permanent symptom connected with 

 the preservative period in the case of No. 1 was a feeling of hunger, 



