SALICYLIC ACID AND SALICYLATES. 495 



the feeling of hunger continuing during the next day. On Novem- 

 ber 12, at 3.40 p. m., the patient was seized with cramps in the abdo- 

 men but not of a very severe character. At the beginning of the 

 fourth preservative subperiod the feeling of hunger had disappeared, 

 but the slight cold in the head continued without notable rise of tem- 

 perature. The cold continued on the 14th, with the feeling of uneasi- 

 ness in the stomach, which feeling disappeared on the 15th, the cold 

 continuing but not in a disturbing degree. Normal conditions were 

 restored on the 16th. On the 17th the subject was still hungry after 

 taking the usual meals and had an uneasy feeling in the stomach. 

 During the fifth preservative subperiod the feeling of hunger per- 

 sisted. A tendency to diarrhea developed on the 19th, and there was 

 some discomfort from indigestion. A little cold persisted during the 

 following days but not of any serious nature, and the sensation of 

 hunger continued. The sixth preservative subperiod began with 

 pains in the stomach and abdomen but with the feeling of hunger con- 

 tinuing. On the 2ith the pains in the stomach were marked, especially 

 after meals; the slight cold continued but without notable increase of 

 temperature. Although still hungry on the 25th, there was a feeling 

 as of a lump in the stomach and other unpleasant sensations, described 

 as "unusual" feelings in the stomach. This indisposition continued 

 on the 26th, and the temperature was slightly below the normal. At 

 6.45 p. m. of this da} r considerable nausea developed, and most of the 

 dinner was vomited. A cold and sore throat were complained of on 

 the 27th, the last day of the preservative period. The temperature 

 on the afternoon of this day was considerably above the normal, and 

 the weight was 56.51 kilograms, the average weight for the entire 

 preservative period being 56.94 kilograms, a decided decrease. 



At the beginning of the after period the temperature was normal, 

 but a slight sore throat persisted which continued also on the follow- 

 ing three days. The feeling of hunger also was reported at times 

 during this period. In the second after subperiod there was a -slight 

 headache and some continued cold, but the cold in general was better. 

 The weight continued to diminish. On the 5th of December normal 

 symptoms were fully reestablished in every particular, but there was 

 a slight feeling of indigestion after dinner. Eight grains of quinine 

 had been taken in the preceding two or three days. On December 6 

 normal symptoms and normal appetite were reestablished, and these 

 continued until the end of the after period, at which time the weight 

 was 55.80 kilograms. 



To summarize, the average weight of No. 6 for the fore period was 

 58.06 kilograms; for the preservative period, 56.94 kilograms; and 

 for the after period, 55.87 kilograms, showing a loss of 1.12 kilograms 

 in the preservative period from the fore period and 1.07 kilograms in 



