SALICYLIC ACID AND SALICYLATES. 497 



had fallen to 66.80 kilograms and the illness of the preceding days had 

 passed away ; the appetite was restored and a sensation of hunger was 

 complained of after the regular meals. This feeling of hunger con- 

 tinued for several days, and on the 26th the illness before complained 

 of again appeared but passed away on the following day. 



The subject started on the after period with a weight of 66.90 kilo- 

 grams, pulse and temperature normal, but complaining of constipa- 

 tion. On the 29th he felt quite well, but during the succeeding days 

 there was a continued loss of weight, although the regular rations 

 selected at the fore period were eaten and the subject felt well. In 

 the second part of the after period the weight fell below 66 kilograms, 

 but the subject was feeling well. This condition of health was con- 

 tinued to the end of the after period. The weight on the last day of 

 the after period was 66.83 kilograms and the average weight for the 

 after period was 66.34 kilograms. 



Comparing the average weights of the three periods, we have for 

 the fore period 67.91 kilograms, for the preservative period 67.28 

 kilograms, and for the after period 66.34 kilograms. 



No. 8.W. C. L. 



No. 8 was a somewhat peculiar subject, very conscientious and very 

 attentive to every detail, but much inclined at all times to imagine 

 that he had some specific or general trouble. The data which were 

 obtained with No. 8, therefore, are of peculiar interest. He was in a 

 very good physical condition at the time of the beginning of the 

 experimental work and in the physical examination revealed no lesion 

 of any vital organ, nor had he suffered from any severe disease for a 

 period of more than a year. His weight at the beginning of the fore 

 period was 61.30 kilograms and his temperature and pulse were normal. 

 He entered the preservative period weighing 60.65 kilograms. On 

 the 1st of November a slight headache was developed early in the 

 morning, which continued until the afternoon, when, after the subject 

 had slept for forty minutes, it disappeared. An unpleasant feeling 

 in the abdomen was experienced at the same time. It should be stated 

 here that during the whole of the observation No. 8 took regularly a 

 given quantity of laxative, administered in such a way that it could 

 not interfere with any of the observations, inasmuch as it was the same 

 during all the periods. A feeling of languor was experienced on the 

 4th of November, and it was reported as having been experienced for 

 several preceding days. *A. slight headache was noted on the 5th of 

 November, but it passed away after breakfast; the subject felt tired 

 on waking. A sore knee with which he entered the preservative 

 period gave him some little trouble at this time, due, as he explained, 

 to hitting it accidentally. On the 8th of November a slight tendency 



