SALICYLIC ACID AND SALIC YLATES. 541 



No. 11. 



A very minute quantity of albumin is noticed in the urine during 

 the administration of the salicylic acid. The reaction of the urine 

 changed from amphoteric in the fore period to acid during the pre- 

 servative period. 



No. 12. 



No albumin occurs in the urine during the periods of observation. 

 The reaction of the urine is changed from amphoteric in the fore 

 period to strongly acid in the second preservative subperiod, becoming 

 amphoteric again in the third preservative subperiod. 



In so far as these data are concerned no effect upon the presence of 

 albumin nor upon the relative acidity can be attributed to the admin- 

 istration of the salicylic acid. A more detailed study of these points, 

 leading to more definite results, is to be found under Series XI, 

 page 726. 



KATIO OF SULPHUR, SULPHATES, AND PHOSPHORIC ACID TO NITROGEN 

 EXCRETED IN THE URINE. 



In Table IX are found the data showing the ratio of sulphur, sul- 

 phates, and phosphates excreted to the nitrogen in the urine. The 

 total weight of nitrogen excreted, the total weight of sulphur, the 

 total weight of sulphur as SO 3 , and the total weight of phosphorus as 

 P 2 O 5 served as a basis for determining the ratios. 



The object of this study was to ascertain whether or not the adminis- 

 tration of salicylic acid changed in any definite way the ratio of these 

 bodies to the total nitrogen excreted. When the ratio increases it 

 shows that there is a loss in the quantity of the substance under con- 

 sideration excreted in relation to the total nitrogen, and when the 

 ratio decreases it shows that there is an increased quantity of that 

 substance in relation to the total nitrogen. 



INDIVIDUAL DATA. 



No. 1. 



The data show a slight decrease in the ratio of sulphur to nitrogen 

 and of sulphuric acid to nitrogen during the administration of the pre- 

 servative, while the ratio of the phosphoric acid to the nitrogen 

 remains unchanged. In the after period there is a still further 

 decrease in the ratio of ^ulphur to nitrogen, while the ratio of sul- 

 phuric acid to nitrogen is restored to its original magnitude. There 

 is a notable increase in the ratio of the phosphoric acid to nitrogen in 



the after period. 



No. 2. 



There is a marked decrease in the magnitude of the ratio of sulphur 

 to nitrogen and of phosphoric acid to /nitrogen in the preservative 



