SALICYLIC ACID AND SALIC YLATES. 561 



No. 12. 



In this case there is a decrease in the percentage of neutral sulphur 

 in the preservative period, while in the after period the loss is partially 

 restored, with corresponding inverse changes in the percentage of total 

 sulphates. There is little difference in the percentage of ethereal sul- 

 phates in the fore and preservative periods and a notable loss in the 

 after period. The percentage of inorganic sulphates is slightly 

 increased in the preservative period and is almost the same in the 

 after as in the preservative period. 



SUMMARY FOR NINE MEN. 



It is seen that the average quantity of sulphur exhibited in the foods 

 is greater in the preservative period than in the fore period, and 

 decreases in the after period (Table XVII, p. 645). This fact must 

 be taken into consideration in the study of the table in regard to the 

 actual weight of the different kinds of sulphur found in the urine, and 

 also in connection with the ratio of the ethereal to the inorganic sul- 

 phates. This ratio, it is seen, in general is almost 1 : 11, being slightly 

 less in the preservative period than in either of the others. The per- 

 centage of the total sulphur occurring as neutral sulphur is 0.7 greater 

 in the preservative period than in the fore period, and the increase is 

 much more marked in the after period, amounting to 1.3 per cent. 

 There is a corresponding decrease in the percentage of total sulphates, 

 since the neutral sulphur and the total sulphates make up the whole 

 quantity of sulphur. The ethereal sulphates and the inorganic sul- 

 phates, expressed as SO 3 , together make up the total sulphates. It is 

 seen that there is a slight increase in the percentage of ethereal sul- 

 phates in the preservative period, while in the after period the per- 

 centage of ethereal sulphates falls slightly below that of the fore 

 period. There is a slight decrease in the inorganic sulphates in the 

 preservative period, and a still further decrease of about the same 

 magnitude occurs in the after period. 



A general summary of the data shows that the administration of the 

 salicylic acid produces a well-marked tendency to increase the per- 

 centage of neutral sulphur with a corresponding decrease of total 

 sulphates during the administration of the preservative, and that this 

 tendency is continued, as might well be expected, in the after period. 

 On the other hand, the administration of the salicylic acid appears 

 to have had no notable effect in disturbing the relative percentages of 

 ethereal sulphates and the inorganic sulphates in the urine. It must 

 be admitted, therefore, in the light of these data, that the principal 

 disturbing effect of the preservative has been upon the relative pro- 

 portion of neutral sulphur excreted. 



