SALICYLIC ACID AND SALICYLATES. 575 



vidual during the time specified. Each sample represented the urine 

 collected during the twenty-four hours preceding its examination. 

 The difficulty in keeping the sample and the time necessary for its 

 examination made this method of procedure necessary. 



DISCUSSION OF OBSERVATIONS. 



Uric acid crystals and urates. No crystals of uric acid were found 

 during the observations, with the exception of one instance during the 

 preservative period in the case of No. 9, when very few are recorded. 

 Urates were also absent throughout the tests. 



Crystals of 'calcium oxalate. These crystals were found in all cases. 

 In the case of No. 1 they were numerous in one instance in the after 

 period; in the case of No. 2 they were numerous in two instances, 

 once during the preservative period and once during the after period, 

 and in the case of No. 11 they were found to be numerous once during 

 the preservative period. The relative occurrence of these crystals 

 during the three periods (determined by dividing the total for each 

 period by the number of observations and multiplying by 100) indi- 

 cates a marked tendency on the part of the preservative to increase the 

 calcium oxalate crystals in the urine, and this tendency is continued 

 to a more marked degree in the after period, the figures being 41.7 for 

 the fore period, 85.4 for the preservative period, and 91.3 for the 

 after period. 



Crystalline phosphates. No crystalline phosphates were present in 

 the cases of Nos. 5, 6, 7, 8, and 9, and in three other cases, namely, 

 Nos. 3, 4, and 12, only a very few were present in one or two instances. 

 Nos. 1, 2,- and 11 showed the largest numbers present, and they occurred 

 principally in the preservative period, being numerous in one instance 

 in the case of No. 1, extremely numerous in the case of No. 2, and 

 fairly numerous in the case of No. 11. The figures giving the relative 

 occurrence show a very slight increase during the preservative period, 

 and a marked decrease in the after period, the figures for the three 

 periods being 50, 52.1, and 39.1, respectively. 



Amorphous phosphates. No amorphous phosphates were found in 

 the cases of Nos. 5, 6, 7, 8, 9, and 12. The report for No. 1 shows 

 that they were numerous in the fore period and at the first three 

 examinations of the preservative period, were not present at all in the 

 last observation of that period and the first one of the after period, 

 but were extremely numerous at the last examination. Nos. 2 and 3 

 have no amorphous phosphates present in the fore and after periods, 

 and only a very few at one observation of the preservative period. 

 The report for No. 4 shows that they were fairly numerous in the fore 

 period and were not again present. In the case of No. 10 they were 

 numerous in the fore period and at the first observation in the pre- 

 servative period, and did not appear again. In the case of No. 11 

 they did not occur until the after period, when the two observations 



