

SALICYLIC ACID AND SALICYLATES. 587 



No. 7. 



The quantity of nitrogen exhibited in the food during the fore 

 period in the case of No. 7 is 139.42 grams, equivalent to 13.94 grams 

 per day; 6.80 per cent is excreted in the feces and 85.76 per cent in 

 the urine. The nitrogen balance is strongly positive, 1.03 grams per 

 day. The quantity of nitrogen in the food during the preservative 

 period is 405.53 grams, equivalent to 13.52 grams daily. Of this 

 quantity, 5.02 per cent is excreted in the feces and 80.19 per cent in 

 the urine. In this case the nitrogen balance is very large, having 

 been increased to 2 grams per day. The total quantity of nitrogen 

 exhibited in the food in the after period is 136.04 grams, equivalent 

 to 13.60 grams per day; of this amount, 8 per cent is excreted in the 

 feces and 80.04 per cent in the urine. The nitrogen balance remains 

 strongly positive, but is decreased to 1.62 grams per day. These data 

 are exactly contrary to those obtained in the former case (No. 6) in 

 that they show a distinct effect of the preservative, in this instance in 

 inhibiting the excretion of the metabolized -nitrogen; the nonmetabo- 

 lized nitrogen excreted is also decreased, while in the case of No. 6 it 

 remained practically constant. 



No. 8. 



The quantity of nitrogen exhibited in the food of the fore period in 

 the case of No. 8 is 129.07 grams, representing a daily quantity of 

 12.91 grams. Of this 9.04 per cent is excreted in the feces and 83.99 

 per cent in the urine. The nitrogen balance is positive and has an 

 average magnitude of +0.90 gram per day. The quantity of nitro- 

 gen in the food during the preservative period is 398.71 grams, with 

 an average daily magnitude of 13.29 grams. Of this quantity 9.88 

 per cent is excreted in the feces and 80.87 per cent in the urine. The 

 balance is strongly positive and has increased to 1.23 grams per day. 

 These figures indicate that the preservative has decreased the excretion 

 of metabolized nitrogen about 3 per cent and increased the excretion 

 of nonmetabolized nitrogen 0.84 per cent. 



During the after period the nitrogen administered in the food 

 amounts to 135.19 grams, equivalent to 13.52 grams per day; 11.53 

 per cent of this nitrogen is excreted in the feces and 88.42 per cent ir 

 the urine. The balance remains positive, but is very small, amounting 

 only to 0.01 gram. It is thus seen that in the after period the excre- 

 tion of the metabolized nitrogen increased greatly, almost 8 per cent, 

 exceeding that of the fore period, and the excretion of nonmetabolized 

 nitrogen continued to increase also. 



Nos. 9 and 10. 



The balances in these two cases of 3 and 4 grams show plainly that 

 some radical error is present. The subjects evidently either did not 

 collect and deliver for analysis the whole of the excreta, or ate food 



