SALICYLIC ACID AND SALIC YLATES. 



613 



ing summary of the results obtained by periods for the nine men is 

 repeated for convenience in the discussion: 



TABLE XIV. Phosphoric acid summary, by periods, for nine men, Series VI. 



It is seen that the average quantities of phosphoric acid ingested 

 daily in the different periods varied but little. There is, however, a 

 slightly larger amount found in the food during the preservative 

 period than in the fore period, while the food of the after period 

 contains an intermediate amount. 



The quantity of phosphoric acid contained in the feces is decidedly 

 smaller during the preservative period than in either of the other 

 periods, amounting to 1.145 grams daily as compared with 1.247 

 grams in the fore period and 1.335 grams in the after period. These 

 average figures, agreeing as they do with the individual figures in 

 every case, show a very distinct effect of the salicylic acid in increas- 

 ing the absorption of the phosphc ric acid from the alimentary canal 

 into the circulation. In respect of the phosphoric acid in the urine it 

 is seen that the amounts during the fore and preservative periods are 

 almost exactly the same, being 2.364 and 2.374, respectively. In the 

 after period, however, there is a very decided indication that upon 

 the withdrawal of the salicylic acid after the preservative period of 

 six weeks the quantity of phosphoric acid in the feces was increased 

 to a marked degree, while the amount in the urine was diminished. 

 The relative percentages of phosphoric acid excreted in the feces and 

 urine show these relations in a still more pronounced manner. 



It thus appears that the effect of the salicylic acid is first to increase 

 the absorption of the phosphoric acid from the intestinal canal, but 

 upon the withdrawal of the preservative much less of the phosphoric 

 acid is absorbed than before the exhibition of the drug. Considering 

 the after period, therefore, the evident conclusion is that the final 

 effect of the salicylic acid has been to diminish the metabolization of 

 the phosphoric acid, and the same conclusion is reached from a study 

 of the percentage data for 1 the amounts excreted in the urine, which 

 decrease steadily from 61. 95 per cent in the fore period to 59.84 in 

 the preservative period and 56.32 per cent in the after period. 



The most prominent fact brought out by the summary is that during 

 the administration of this preservative the feces are more free from 

 phosphoric acid than during the fore and after periods and there is 

 practically no increase in the amount excreted in the urine, while the 



