708 INFLUENCE OF FOOD PRESERVATIVES ON HEALTH. 



The administration of the salic} 7 lic acid apparently produced an increase 

 in the volume of urine, which tendency continued during the after 

 period. 



During the fore period the average daily nitrogen eliminated in the 

 urine is li.653 grams, during the preservative period 13.286 grams, 

 and during the after period 14.566 grams. These data show a slight 

 tendency on the part of the preservative to decrease the amount of 

 nitrogen eliminated in the urine. A comparison of the nitrogen in 

 the urea by the two methods of observation shows quite concordant 

 results. Unfortunately the determination of the total nitrogen elimi- 

 nated in the urea for the after period in the composite sample was lost. 

 There is distinctly less nitrogen eliminated as urea in the preservative 

 period than in the fore period. In respect of uric acid nitrogen the 

 average daily quantity eliminated in the fore period is 0.243 gram in 

 the composite sample, in the composite sample of the preservative 

 period 0.210 gram, and in the composite sample of the after period 

 0.258 gram. These data also show a distinct diminution in the amount 

 of uric acid nitrogen eliminated during the administration of the sali- 

 cylic acid. 



The study of the total quantities and percentages of urea and uric 

 acid eliminated is a matter of interest. The total quantities of urea 

 eliminated, as determined by the two methods, are practically the 

 same, and the comparison will be based upon the first method alone. 

 It is seen that the average daily weight of urea eliminated in the fore 

 period is 28.346 grams in the composite sample. For the composite 

 sample of the preservative period it is 25.75 grams. There was no 

 composite sample examined for the after period. The average for the 

 daily examinations of the after period shows an elimination of 28.511 

 grams of urea daily. These data show a markedly depressing effect 

 produced by the preservative upon the quantity of urea eliminated. 

 In respect of uric acid, the average daily quantity eliminated in the 

 fore period, as determined in the composite sample, is 0.727 gram, in 

 the preservative period in the composite sample 0.628 gram, and in 

 the composite sample of the after period 0.772 gram. We find here 

 again a marked tendency on the part of the preservative to diminish 

 the average weight of the uric acid eliminated. The ratio of the uric 

 acid nitrogen to the total nitrogen eliminated in the fore period in the 

 composite sample is 60.3, in the preservative period in the composite 

 sample 63.3, and in the after period in the composite sample 56.5. 

 This ratio shows that the depressing effect of the preservative upon 

 the elimination of nitrogen is exerted more powerfully upon the 

 nitrogen in uric acid than on the other nitrogenous constituents. 



In the fore period the average daily percentage of ingested nitrogen 

 which is eliminated in the urine is 93.6 in the composite sample, in 

 the composite sample of the preservative period 84,8, and in the com- 



