SALICYLIC ACID AND SALICYLATES. 709 



posite sample of the after period 93. Thus it is seen that the exhibi- 

 tion of the preservative has diminished in a marked degree the per- 

 centage of the total nitrogen of the food eliminated in the urine. 

 Confining the comparison to the first method for the determination of 

 the urea, it is found that 90.4 per cent of the total daily nitrogen 

 eliminated in the urine is eliminated as urea during the fore period, 

 90.5 per cent during the preservative period, and 91.5 per cent in the 

 after period, showing that the administration of the preservative has 

 not changed the percentage amount of nitrogen eliminated as urea to 

 any great extent. 



The percentage of total nitrogen that is eliminated as uric-acid nitro- 

 gen in the fore period is 1.7 per cent in the composite sample, in the 

 preservative period 1.6 per cent in the composite sample, and in the 

 after period 1.8 per cent in the composite sample. Again, there is a 

 very slight tendency shown here on the part of the preservative to 

 diminish the percentage of uric-acid nitrogen eliminated. 



No. 2. 



In the case of No. 2 the average daily volume of urine in the fore 

 period is 1,037 cc, the average daily volume in the preservative period 

 is 1,212 cc, and the average for the after period 1,863 cc. The aver- 

 age for the after period, however, is only for two days, as the urine 

 for the second day was lost. These data show a slight diuretic effect 

 of the salicylic acid during the period of administration, and this 

 effect is increased enormously in the after period, which can only be 

 attributed to the continued action of the drug. 



The average daily quantity of nitrogen eliminated in the urine in 

 the fore period is 13.473 grams, in the composite for the preservative 

 period 13.664 grams, and in the composite for the after period 13.279 

 grams. These data show a slight increase in the elimination of nitro- 

 gen in the urine during the administration of the preservative, both 

 over the fore period and over the after period. The quantities of 

 nitrogen eliminated as urea, determined by the two methods, agree 

 very well. There was no composite, however, examined for the after 

 period. There was a slight increase in the amount of nitrogen excreted 

 as urea during the preservative period. In respect of uric acid, the 

 average daily amount of nitrogen eliminated in the form of uric acid 

 in the fore period in the composite sample is 0.168 gram. In the com- 

 posite sample for the preservative period it is 0.156 gram, and for the 

 after period 0.139 gram. Again, we find here a tendency manifested 

 by the preservative to diminish the excretion of nitrogen in the form 

 of uric acid. 



The average daily quantity of urea excreted by No. 2 in the fore 

 period is 25.727 grams in the composite sample; in the composite 

 sample for the preservative period 26.669 grams, and for the average 



