SALICYLIC ACID AND SALICYLATES. 733 



In the after period the percentages are restored almost to their 

 original value in the fore period. 



In general it appears, therefore, that in the case of No. 1 the 

 salicylic acid has a stimulating effect upon the excretion of nitrogen 

 in the urine, but does not increase either in quantity or percentage the 

 amount of uric acid excreted, but does slightly increase the proportions 

 of kreatinin, urea, arid ammonia excreted. 



In the case of No. 2 the volume of urine was very much greater 

 than in the case of No. 1 and the quantities of total solids are cor- 

 respondingly increased. There is a progressive decrease in the total 

 nitrogen excreted in the urine, the daily quantity in the fore period 

 being 17.63 grams, in the preservative period 16.04 grams, and in the 

 after period 13.84 grams. This corresponds with the decrease in the 

 volume of the urine during these periods. A similar decrease is found 

 also in the quantity of urea and the other nitrogenous constituents, all 

 except kreatinin and xanthin being more or less diminished in quantity. 



The total weight of urea daily excreted in the fore period is 35.02 

 grams, in the preservative period 31.56 grams, and in the after period 

 27.22 grams. It would appear that the exhibition of the salicylic acid 

 tends to interfere with the metabolism of the nitrogen as manifested 

 in the urine, and these indications are of an opposite character to 

 those shown in the case of No. 1. 



Of the total nitrogen in the food there was excreted in the urine 

 during the fore period of No. 2 85.6 per cent, during the preservative 

 period 77.9 per cent, and during the after period 67.2 per cent. If the 

 relations of the various nitrogenous constituents in the urine be con- 

 sidered it will be seen that there is but little variation in the excretion 

 of urea nitrogen in relation to the total nitrogen in the urine. During 

 the fore period 92.8 per cent is excreted as urea; during the preserva- 

 tive and after period 91.9 per cent. In the fore period 1.1 per cent 

 of the total nitrogen in the urine is excreted as uric acid, 1 per cent 

 in the preservative period, and 1.2 per cent in the after period. The 

 percentage of nitrogen excreted as kreatinin (based on the total nitro- 

 gen in the urine) is 3.4 in the fore period, 4.0 in the preservative period, 

 and 3.6 in the after period. For ammonia the figures are 1.9 per cent 

 in the fore period, 1.4 per cent in the preservative period, and 1.9 per 

 cent in the after period. 



These data show that the mass effect in No. 2 was to inhibit in a very 

 striking manner the metabolism of the nitrogen, but that the urine 

 retained its normal composition in respect of the relative amounts of 

 nitrogenous constituents, although the excretion of nitrogen was pro- 

 gressively diminished throughout the preservative and after periods. 



