SALICYLIC ACID AND SALIC YLATES. 735 



in the after period. In this connection attention is called to the fact 

 that the quantity of nitrogen ingested in the food was somewhat 

 greater in the preservative period and after period than in the fore 

 period. But the total quantity of nitrogen excreted in the urine was 

 considerably less in the preservative period than in the fore period, 

 although the amount ingested is greater. There was some tendency 

 to a larger excretion in the after period, but it did not reach the 

 amount found in the fore period, in spite of the larger quantity of 

 nitrogen in the food. The uric acid in this case is again less in quan- 

 tity in the preservative period than in the fore period, but is restored 

 to the amount of the fore period in the after period. There appears to 

 be no effect upon the amount of kreatinin excreted, while the ammonia 

 is somewhat less in the preservative period than in the fore period. 



In regard to the total quantities of the various nitrogenous constit- 

 uents in the urine it is seen that the amount of urea excreted is mark- 

 edly less in the preservative period than in the fore period, and some- 

 what increased over the preservative period in the after period. The 

 quantity of uric acid excreted during the preservative period is mark- 

 edly less than in the fore or after period. There was no appreciable 

 effect produced by the sodium salicylate upon the amount of kreatinin 

 excreted. The ammonia is less in the preservative period than in either 

 of the other periods. In the study of the distribution of the nitrogen 

 among the various nitrogenous elements it is seen that an abnormal per- 

 centage of nitrogen in the food is excreted in the urine, amounting to 99 

 per cent in the fore period, 84.4 per cent in the preservative period, and 

 88.8 per cent in the after period. The administration of the salicylate 

 of soda did not have any effect on the proportions of nitrogen excreted 

 as urea, these being 90 per cent, 90.1 per cent, and 90.2 per cent, 

 respectively, for the three periods. 



Again, it is found that the percentage of nitrogen excreted as uric 

 acid is diminished in the preservative period, and is restored in the 

 after period. The percentage of nitrogen excreted as kreatinin is 

 slightly larger in the preservative period than in either of the other 

 periods, while the percentage of nitrogen excreted as ammonia is less. 



In this case it is noticed that the administration of the preservative 

 tends to restrict the activity of nitrogen metabolism, that it has a dis- 

 tinct tendency to diminish the amount of uric acid excreted, and that 

 it does not produce any other very marked effect upon the distribution 

 of the nitrogen in the different nitrogenous components of the urine. 



SUMMARY FOR NOS. 1 AND 2. % - 



It is convenient, for purposes of comparison, to consider first the data 

 for Nos. 1 and 2, they having received salicylic acid, then those for 

 Nos. 11 and 12, they having received equivalent amounts of salicylate 



