SALICYLIC ACID AND SALICYLATES. 737 



SUMMARY FOR NOS. 11 AND 12. 



In the case of Nos. 11 and 12 there is an increase in the volume of 

 urine in the preservative period and a slight tendency to decrease in 

 the after period. In regard to the total solids excreted in the urine, 

 the amount is found to be considerably greater in the preservative 

 period, amounting to 55.3 grams as compared with 50.3 grams in the 

 fore period. The amount in the after period falls to 51.3 grams, only 

 slightly greater than in the fore period. By reason of an increase in 

 the bread ration of No. 12 the amount of nitrogen ingested in the food 

 is greater in the preservative period and the after period than in the 

 fore period. The total weight of the nitrogen excreted in the urine 

 during the fore period is 12.52 grams daily, during the preservative 

 period 12.75 grams, and in the after period 13.05 grams, showing a 

 gradual increase in the nitrogen in the urine. As urea, 11.32 grams 

 of nitrogen were excreted in the fore period, 11.47 grams in the pre- 

 servative period, and 11.90 grams in the after period. In the case of 

 uric acid there is again a decrease in the nitrogen excreted as uric acid 

 in the preservative period and a slight increase in the after period 

 over that of the fore period. There is an increase in the amount of 

 nitrogen excreted as kreatinin in the preservative period, from 0.47 

 gram to 0.51 gram, dropping back to 0.48 gram in the after period. 

 There is a slight decrease in the amount of ammonia excreted during 

 the preservative period. 



Of the nitrogen in the food, 84 per cent is excreted in the urine 

 during the fore period, 82.4 in the preservative period, and 84.2 in 

 the after period, thus showing a decrease of 1.6 per cent in the 

 amount of nitrogen metabolized in the preservative period. In regard 

 to the percentage of nitrogen excreted in the various constituents it is 

 seen that there is but little influence of the preservative upon the per- 

 centage excreted as urea, it being 90.4 per cent in the fore period, 90.0 

 per cent in the preservative period, and 91.3 per cent in the after 

 period. There is a decrease in the percentage of nitrogen excreted as 

 uric acid in the preservative period and a slight increase in the per- 

 centage of nitrogen excreted as kreatinin, while that excreted as 

 ammonia is slightly less in the preservative period. 



GENERAL SUMMARY. 



In the general summary of the four men the average daily volume 

 of urine is 1075 cc in the fore period, 1084 cc in the preservative 

 period, and 1032 cc in the after period. The total solids of the urine 

 are 57.1 grams for the fore period, 59.3 grams for the preserv- 

 ative period, and 54.4 grams for the after period, these data showing 

 an increased excretion in the preservative period and a markedly 

 decreased excretion of total solids in the after period. 



