670* 



Cancer Research 



Blamd-Sutton, 1885: In the stomach of each of 

 two codfish Gcdus morkua was a pale gray tumor 

 which on section was found to be composed of inter- 

 lacing bundles of glistening white connective tissue. 



Rvoca, 1887: Described a hbroma near the pylorus 

 of a thwaite shad (dted by Thomas, 1931 b). 



Pleun, 1906: A tumor the size of a hen's egg was 

 attached to the peritoneum of a crucian carp Carassius 

 carassius by a short pedicle. The mass was firm and 

 had a smooth surface; the cut surface was pale pink. 

 Histologically the tumor was a typical fibroma and was 

 noade up of interlacing bands of connective tissue. A 

 few small areas of necrosis were present, no mitoses 

 were found. Several smaller fibromas were scattered 

 over the surface of the mesentery. 



Plehn, 1906: A firm tumor the size and shape of 

 a hen's egg was found in the coelom of a bream Abramis 

 brama. The neoplasm was composed of short spindle 

 cells and fibers ; no mitoses were found, no inflammatory 

 cell infiltrates were present 



PiXHN, 1906: A pink tumor 3 z 2.5 cm., was present 

 in the trunk muscles of a pike Esox lucitis. The paren- 

 chyma was composed of connective tissue cells arranged 

 in bundles, with many fat cells scattered among them. 

 Mitoses were uncommon; occasional giant cells with 

 peripheral nuclei were present. The author called the 

 tumor a lipofibroma. 



FiEBiGER, 1909 a: Arising from the oral mucous 

 membrane of a codfish Pollachius virens was a tumor 

 the size of a pigeon egg that consisted of bundles of 

 connective tissue covered by a thick layer of epithelium. 



WOUAIISON, 1909: The author reported a fibroma 

 of the esofdiagus in a codfish Gadus morhua. 



JOH.NSTONE, 1911: A fibroma 5.8 x 3.3 x 2.3 cm. 

 was attached to the peritoneum in the region of the 

 caecum of a sardine Arengus pUchardus. The surface 

 was nodular and yellow-white in color. Histologically 

 the tumor was composed of interlacing bundles of con- 

 nective tissue. 



Johnstone, 1911: Behind the operculum of a 

 haddock MeUmogrammus aeglifinus was a well encap- 

 sulated tumor 7x6x6 cm. made up of bundles of 

 mature connective tissue. 



Johnstone, 1913: A retroperitoneal fibroma weigh- 

 ing 2.5 kg. was found in a halibut Hippo glossus 

 Uppo^sxus. The tumor, which was soft and friable 

 and had a smooth, lobulated surface, was made up of 

 bundles of connective tissue. 



Johnstone, 1914: Multiple fibromas were found 

 in the trunk muscles of a halibut Hippoglossus hippo- 

 ffexMf . They were well encapsulated and could readily 

 beihdledout 



JOHNtTONi, 1914: In the left orbit of a codfish 

 Godm morkua was a firm gray white tumor 7 x 6 cm. 

 The overlying skin was intact; the eye was displaced 

 poeterioriy and downward. The neoplasm was well en- 

 capsulated and consisted of interiacing bundles of con- 

 nective tissue. 



RoMCA, 1914: A tumor the size of a hen's egg arose 

 in the mesentery of a carp CypHmu carpio. White in 



color, it was soft in consistency and was made up of 

 interlacing bundles of connective tissue. 



Waco, 1922: Multiple tumors, 0.5 cm. in diameter, 

 were scattered over the body surface, fins, and eyes of 

 a goldfish Carassius auratus. Spheroidal or polypoid in 

 shape, they were smooth, not covered by scales, and 

 firm in consistency. The cut surface was red and trans- 

 lucent. Histologically there was an abundance of deli- 

 cate connective tissue and fusiform fibroblasts mingled 

 with irregularly shaped cells widely separated from one 

 another. No inflammatory cell infiltrates were seen. 

 Though several fish with similar lesions were found in 

 the same garden pool, an infectious agent could not 

 be demonstrated. The author identified the tumor as 

 myxofibroma. 



Johnstone, 1922: On the pigmented side of the 

 dorsal fin of a plaice Pleuronectes platessa was a firm 

 spherical tumor 3.5 x 3 cm.; on microscopic examimt- 

 lion it proved to be a typical fibroma. 



Johnstone, 1924: Scattered over the trunk of a 

 haddock MeUmogrammus aeglifinus were local thicken- 

 ings in the corium. Each of these measured about 5 

 mm. in diameter, and was covered by normal epidermis. 

 The author identified the lesions as fibromas. 



Johnstone, 1924: On the dorsal fin of a turbot 

 Rhombus maximus was a tumor that measured 1 x IVi 

 inches. Histologically it was a typical fibroma. 



Johnstone, 1925: An immature female sardine 

 Arengus pUchardus bore a tumor 9x4 cm., which ap- 

 parently arose in the peritoneum. The viscera were 

 intact. Microscopically the tumor consisted of irregu- 

 lady arranged bundles of connective tissue abundantly 

 supplied with blood vessels. 



Sagawa, 1925: The author found multiple fibromas 

 on the skin of a goldfish Carassius auratus. The tumors 

 were firm and elastic, yellow-gray, sharply circum- 

 scribed, and varied from the size of a millet seed to that 

 of a pigeon's egg. Histologically they were composed of 

 young connective tissue which, however, did not take 

 van Gieson's stain. Myelinated nerve fibers were also 

 present. (These lesions may have been neurofibromas.) 



Johnstone, 1925: The cardiac end of the stomach 

 of a 16 pound codfish bore a tumor 15 x 10 cm. On 

 section it was white, glistening, and firm in consistency. 

 Histologically the neoplasm was a fibroma. 



Johnstone, 1926: On the nonpigmented side of 

 the head of a halibut Hippoglossus hippoglossus was a 

 mass 8 inches in diameter; the overlying skin was in- 

 tact. The tumor weighed 3 pounds, shelled out readily, 

 was well encapsulated, and histologically was a typi(^ 

 fibroma. 



Johnstone, 1926: Two tumors were present on 

 the head of a plaice Pleuronectes platessa. One on the 

 lower border of the operculum measured 4V4 > 3V4 

 inches, the other was smaller, grew from the anterior 

 border of the right orbit, and partly covered the eye 

 The overiying skin was intact. Both neoplasms con- 

 sisted of bundles of connective tissues; few vessels 

 were present. 



EcucHi and Oota, 1926: A firm elastic tumor 



