674. 



Cancer Research 



growing between muscle fibers and had eroded the under- 

 lying bone. 



PiXBN, 1909 and 1924: A large tumor of the kid- 

 ney was found in a 10 pound pike Esox lucius. It iiad 

 mettastasised to the trunk muscles. Histologic studies 

 were of little value due to poor fixation of the tissue, 

 but the author regarded the tumor as a sarcoma. 



PuHN, 1909 : On the surface of the liver of a large 

 Danubian trout Hucho hucho were white nodules var>-- 

 ing from the size of a millet seed to that of half a 

 walnut. On section they were found not to be circum- 

 scribed, but had invaded the normal tissues. The author 

 identified the lesion as a spindle cell sarcoma. 



FiEBiCEK, 1912: According to the author this is the 

 first record of a fibrosarcoma in a salt water fish, the 

 three previous cases were found in fresh water fishes. 

 A cauliflower-Uke mass the siie of an egg grew in the 

 subcutaneous tissue of a codfish PoUachius virens. It 

 was not sharply demarcated from the adjacent tissue; 

 the overl>'ing skin was ulcerated, and hemorrhages were 

 Dtmierous on the surface of its warty excrescences. The 

 round, elongated, and even branched tumor cells in- 

 filtrated the muscle. 



Duw, 1912: A circular timior, 4x1% inches, was 

 present on the dorsal surface near the lateral fin of a 

 ray Raja macrorkynchus. It was a broadly sessile, cauli- 

 flower-like mass covered by a layer of epithelium. The 

 parenchyma consisted of fibrous tissue apparently de- 

 rived from the perichondrium of one of the fin rays. 

 Nowhere was the tissue very cellular, but because of 

 its mode of growth the author classified it as a sarcoma. 



WoLFT, 1912: A tumor the size of a man's fist lay 

 between the layers of the mesentery of a large eel 

 AnpdUa vulgaris. Histologically, nests of tumor cells 

 surrounded the blood vessels and were separated from 

 one another by bands of connective tissue. The author 

 identified the growth as a fibrosarcoma. 



JoHNSTOKK, 1912: On the snout of a codfish Gadus 

 morhwa was a gray-black non-encapsulated tumor, 7.5 

 z 4 z 3 cm. The superficial epidermis was destroyed. 

 Grocily it ^ipeared to be a t>pical fibroma, but his- 

 tologic examination showed evidence of infiltration and 

 increased cellularity. 



Duw, 1912: A plaice PUuronectes plaUssa bore a 

 white ovoid mass, three-fourths of an inch in diameter, 

 on the operculum of the pigmented side. Histologically it 

 was made up of connective tissue. No further details 

 were given, and the growth was Usted as sarcoma by the 



JOBMSTONE, 1915: On the right side of an emaciated 

 codfish Gudus morhua between the first ventral and 

 second dorsal fin was an 8 cm. timior that had invaded 

 the adjacent muscle fibers and undergone central lique- 

 faction necrosis. The tumor cells were spindle shaped; 

 occarional giant cells were present. 



Bkatti, 1916: Numeroiis subcutaneous nodules were 

 picaent on each opercultmi. on the snout, on the body, 

 and on one side of the tongue of a croaker Pogomas 

 ckromis. The parenchyma consisted of densely grouped 

 ipindle ceUs with abundant cytoplasm and nnall nuclei. 



Johnstone, 1920: On the top and left side of the 

 head of a conger eel Conger conger were two firm, spheri- 

 cal tumors, each 10 cm. in diameter. Histologically 

 there was no evidence of encapsulation ; the parenchyma 

 presented all the characteristics of a mixed cell sarcoma. 



Johnstone, 1920: Several tumors were present about 

 the left orbit and within the mouth of a codfish. On the 

 basis of their histologic structure the author classified 

 them all as sarcomas of mixed cell type. 



Kazama, 1922: Among 1,000 salmon Oncorhynchus 

 keta the author found a single tumor-bearing animal. 

 In a five year old fish, 85 cm. in length, there was a 

 tumor, 6.5 X 6 X 3 cm., which arose from the body wall 

 near the origin of the right pelvic fin. It was hemispheri- 

 cal, gray-white, and encroached on the peritoneal cavity. 

 The tumor was composed of fusiform cells that de- 

 stroyed and infiltrated the surrounding tissues; no mi- 

 toses were seen. 



Johnstone, 1922: On the top of the head of a had- 

 dock Melanogrammus aegUfinus was a tumor which the 

 author called a sarcoma. No further details were 

 given. 



ScHAMBERG and LucKi, 1922: A gddfish that had 

 lived in a garden pool for 1 5 years bore three tumors on 

 its right side. The growth which the authors regarded 

 as primary was on the back just anterior to the dorsal 

 fin; it measured 2.6 cm. in diameter and projected 1.5 

 cm. above the skin surface. The other tumors were 

 located near the tail, one measured 1 cm. in diameter, 

 the other 3 mm. All were dull white in color. Infiltra- 

 tion of the underlying muscle had occurred about the 

 largest tumor. Histologically the growths were com- 

 posed of loosely arranged spindle cells ; the blood supply 

 was scanty; the vessels very thin walled. The two 

 smaller tumors did not infiltrate; the authors believed 

 they represented metastases; this interpretation is now 

 regarded as probably erroneous. 



Johnstone, 1923: At the base of the tail of a gold- 

 fish Carassius awatus was a tumor that measured 1 x 1.5 

 cm. Histologically it was made up of proliferating con- 

 nective tissue that had invaded the surrounding muscle. 



Johnstone, 1923: A mass 6x3x3 cm. was located 

 on the anterior border of the right orbit of a codfish 

 Gadus morkua. The connective tissue was abundant, 

 but in some areas there were large numbers of small 

 round cells, the neoplasm infiltrated the dermis and 

 muscle, but the skin was not ulcerated. 



Johnstone, 1923: On the right side of the head of a 

 ling Molva molva, arising above and behind the orbit, 

 was a tumor 11x5 cm. which grew forward over the 

 eye and almost covered the pupil. No histologic details 

 were given; it was classified by the author as a fibro- 

 sarcoma. 



Johnstone, 1923: On the pigmented side of a turbot 

 Rkombus maximus was a tumor 8x3 cm. Histologically 

 the lesion consisted of connective tissue among which 

 were spindle cells. There was little evidence of malig- 

 nancy, although the author diagnosed it a sarcoma. 



Johnstone, 1924: A creamy white tumor, slightly 

 nodular and measuring 3V4 x 1)^ inches, was loosely 



