676i 



Cancer Research 



author regarded the tumor as a brge round cell sarcoma. 

 (LyTnphosarcoma ?) 



Williams, 1931: An egg-shaped tumor, 12.8 z 8.8 

 cm., was present in the trunk muscles of a codtish Gadus 

 morkua. Histologically it consisted of small round ceils 

 embedded in a connective tissue stroma. The tumor was 

 vascular and infiltrated the adjacent muscle. (Lympho- 

 sarcoma ?) 



MYXOBIA 



Although in mammals fully developed mucous 

 tissue is found only in the umbilical cord, it has 

 been described as occurring in certain areas of some 

 fishes, particularly about the cranial cartilage of 

 selachians. Six cases of myxoma have been repK)rted ; 

 these were found in 5 species of fishes, all teleosts 

 (Table 9). Of these, four have been identified by 

 the authors as myxofibromas, the remaining two 

 were classified as myxosarcomas because of their 

 invasive character. 



The benign tumors arose in the subcutaneous 

 tissue; in one case they were multiple, and grouped 

 about the base of the fins. One of the invasive 

 tumors was retro-orbital, the other lay within the 

 tnmk musculature; no metastases were found. 



Abatracts of reported cases of Myxoma 



Plehn, 1906: The right eye of a 6 or 7 year old tench 

 Tinea vulgaris was displaced by a tumor arising below 

 the orbit. It was hemorrhagic, not sharply demarcated. 

 and infiltrated the surrounding tissues. Histologically, 

 some areas consisted of dense masses of spindle cells; 

 in other regions these were separated by a mucoid 

 ground substance in which were many delicate fibrils. 



ScHKOEDEKs, 1908: On the pigmented side of a 

 flounder Psetta maeotica was a spherical pedunculated 

 tumor 9 z 12 z 7 cm. The overlying skin was intact. 

 The mass was elastic in consistency and translucent on 

 section, with numerous transecting fibrous bundles. Mi- 

 croscopically the large spaces between the interlacing 

 bundles of connective tissue were filled with an amor- 

 phous substance (mucin) that stained blue with hema- 

 toz>'lin. Within this were scattered stellate cells. Large 

 blood vessels coursed along the fibrous trabeculae. 



ScHKOEDESS, 1908: About 10 tumors were present at 

 the junction of the trunk and fins of a flounder Psetta 

 maeotica. Most were broadly sessile; in a few the over- 

 lying skin was ulcerated. Elastic in consistency, the 

 tumors on section were translucent and yellow-whit(* 

 Histologically, interbcing bundles of connective tissue, 



mostly arranged perpendicular to the skin, formed a 

 coarse network, in the meshes of which was an amor- 

 phous ground substance containing stellate cells. 



MacLntosh, 1908: A plaice PUuronectes platessa 

 bore an elongated swelling on its right side. On dissec- 

 tion the tumor was gelatinous in consistency; the sur- 

 rounding muscle was atrophied and the growth could be 

 removed with ease. Histologically it was a loose, areolar 

 connective tissue, enmeshed in which were many small 

 cells and capillaries. The surrounding structures were 

 not infiltrated. 



Johnstone, 1926: A tumor 2 inches in diameter, 

 irregular in shape, and glistening white in color, was 

 present in the body cavity of a sole Solea solea. His- 

 tologically the growth consisted of interlacing bundles 

 of connective tissue and areas of areolar tissue con- 

 taining stellate cells separated by large interspaces. 



Williams, 1929: A tumor, 12.7 x 5.1 cm., was found 

 in the trunk musculature on the non pigmented side of 

 a turbot Rhombus tnaximus. The overlying skin was 

 ulcerated. Histologically typical myxomatous tissue if 

 filtrated the adjacent muscle. 



CHONDROMA 



Although the entire skeleton of selachians is com- 

 posed of cartilage and this tissue is also abundant 

 in the teleost fishes, only 8 rep)orts of tumors of 

 cartilage can be found in the literature (Table 10). 

 Of these 2 were in selachians; one arose from the 

 fin ray of a cat shark, the other from the lumbar 

 vertebrae of a dogfish. An explanation for this 

 dearth of material may be found in the fact that the 

 selachians are not commonly used for food and are 

 therefore seldom examined; however, the dogfish is 

 frequently dissected in biology laboratories. Mul- 

 sow (140) reported a chondroma attached to the 

 cranial bones in each of three crucian carp Coras- 

 sius carassius. All the tumors were massive and 

 nearly filled the cranial cavity. Unfortunately, no 

 further data are available, but if the animals were 

 siblings, the possibility that the tumors were com- 

 parable to multiple hereditary chondromas of man 

 would need to be considered. There is no record in 

 the literature of a malignant cartilagenous neoplasm 

 of fishes. 



AbHtracis of reported cases of chondroma 



MuLSOW, 1915: A chondroma was found attached to 

 the cranial bones in each of three crucian carp Carassius 



Tabu 9: Myxoma 



SpcdM 

 Tench Titua vulgaris 

 Flounder Ptttta matctka 

 Flounder PsiUa ««<rfrs 

 Flake PUmomeUs plaUssa 

 Sole StUa spUa 

 Turbot Rk^u^ut mcximus 



Site 

 Subcutaneous 

 Skin, head 

 Skin, trunk & fins 

 Body wall 

 Peritooeuro 

 Trunk musculature 



Author 

 Plehn, 1906 

 Schroeders, 1908 

 Schrocders, 1908 

 Macintosh, 1908 

 Johnstone, 1926 

 Williams, 1929 



